An evaluation of the etiological factors of lymphedema following radical mastectomy.An analysis of 1,007 cases

Preventative Measures for Lymphedema: Separating Fact from Fiction

“…The rate of lymphedema in obese patients (they defined by patients over 150lbs) was nearly double that of non-obese patients (49% vs. 28%) and highly statistically significant. Furthermore, the severity of lymphedema also correlated with obesity leading the authors to conclude that obesity is a significant predisposing risk factor 40 .…”

Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma

“…[22][23][24] It commonly is held that lymphedema consequent to the management of breast carcinoma, which can involve the trunk, the ipsilateral upper arm, or the conserved breast, 25 was a predisposing factor to the development of angiosarcoma arising in these areas. These features distinguishing angiosarcoma from other sarcomas may reflect a different radiation-induced mechanism of carcinogenesis between the two types of sarcoma.…”

Lymphatic Vessel Network Structure and Physiology

“…There is growing evidence of a reciprocal connection between lymphatic dysfunction and obesity (681). Obesity has long been known to be a risk factor for secondary, but more recently it has also been shown that extreme obesity can cause lymphedema in the absence of other risk factors (393, 715, 1078). There is also increasing clinical evidence to suggest that obese patients are predisposed to secondary lymphedema and primary lymphedema can induce adult onset obesity (330).…”