An Evaluation of the Antibacterial Activities of Combinations of Sulfonamides, Trimethoprim, Dibromopropamidine, and Silver Nitrate Compared with Their Uptakes by Selected Bacteria

Richards, R. M. E.; Taylor, Robert B.; Xing, Dorothy

doi:10.1002/jps.2600800912

Cited by 46 publications

(8 citation statements)

References 22 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Minimum inhibitory concentrations (MICs), checkerboard MIC values and killing curves were determined for single antibacterials and antibacterial combinations as previously described (Richards et al 1991a, b).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Mechanism for Synergism between Sulphonamides and Trimethoprim Clarified

Richards

Taylor

Zhu

1996

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Pseudomonas aeruginosa, Escherichia coli, Pseudomonas cepacia and Moraxella catarrhalis were selected for their markedly different resistance patterns to sulphonamides and trimethoprim. In addition, strains of E. coli and P. cepacia were selected having different resistance profiles to the inhibition of dihydropteroate synthetase and dihydrofolate reductase. All inhibitors of dihydropteroate synthetase combined in any combination with inhibitors of dihydrofolate reductase resulted in mutual enhancement of bacterial uptakes of the inhibitors and corresponding increased antibacterial activity of the combinations. High concentrations of sulphonamides or p-aminobenzoic acid plus trimethoprim caused a decrease in overall activity of the combination and indicated that both sulphonamides and p-aminobenzoic acid at high concentrations can interact with dihydrofolate reductase. The antibacterial activity of p-aminobenzoic acid at high concentrations is considered to be a blocking effect on dihydrofolate reductase even though p-aminobenzoic acid at low concentrations is an essential part of the synthesis of dihydrofolic acid. These findings support an alternative hypothesis for the mechanism of antibacterial action of individual antifolates and their mechanism of synergism in combination.

show abstract

Section: Antibacterial Activitymentioning

confidence: 99%

Mechanism for Synergism between Sulphonamides and Trimethoprim Clarified

Richards

Taylor

Zhu

1996

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…A new aspect in searching for enhanced bactericidal effect for silver has been demonstrated in some researches on the synergistic effects of ionic silver with different antibiotics used in the treat-ment of burn wound infections [8,9]. Synergistic effects have also been demonstrated for chitosan-silver nanocomposites on strain of Staphylococcus aureus [10], for b-lactam antibiotics combined with silver nanoparticles and on strain of Escherichia coli [11].…”

Section: Introductionmentioning

confidence: 99%

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Mavrodinova

Popova

Yoncheva

et al. 2015

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

by Solid-state Ion Exchange (SSIE) procedure over zeolite Y, followed by deposition of sulfadiazine (SD) by dry mixing was examined for the preparation of topical antibacterial formulations. The ion-exchange and adsorptive properties of the zeolite matrix were utilized for the bactericidal Ag deposition and loading of antibiotic sulfadiazine.Experiments: Assessment of the encapsulation efficiency of both active components loaded by solid and liquid deposition methods was made by X-ray diffraction, TEM, FT-IR spectroscopy and thermogravimetric analysis (TGA). SD release kinetics was also determined.Findings: Sustained delivery of sulfadiazine has been observed from the Ag-modified zeolites compared to the parent HY material. It was found that if SD was loaded in solution, part of the zeolite silver ions was released and interacted with SD, forming AgSD. By solid-state SD deposition, the reaction between the drug and the silver was restricted within the limits of inter-atomic interaction, and total but prolonged drug release occurred.

show abstract

“…Cells of S. aureus treated with AgSD were enlarged, some retraction of the cytoplasmic membrane from the cell wall was seen and division planes between bacteria became indistinct, supporting the view that the effect is on external cell structures [26]. Studies have shown that subinhibitory levels of sulphadiazine affect membrane permeability [27]. This may enhance the entry of silver ions into cells.…”

Section: Introductionmentioning

confidence: 69%

Effects of silver sulphadiazine on the production of exoproteins by Staphylococcus aureus

Edwards-Jones¹,

Foster

2002

Journal of Medical Microbiology

View full text Add to dashboard Cite

The effects of subinhibitory concentrations of silver sulphadiazine (AgSD) on exoprotein production in Staphylococcus aureus strains T1, T4, RN4282 and RN 4282agr were studied. AgSD markedly increased levels of toxic shock syndrome toxin (TSST)-1 in strains T4 and RN4282. This effect was independent of agr and AgSD restored TSST-1 production to the wild-type level in RN 4282agr. AgSD had no effect on enterotoxin A or coagulase activity in strains T1 or T4. Strain T4 produced enterotoxin C at high levels and no effect was observed with AgSD. AgSD repressed metalloprotease production in strain T4 but the overall protease activity remained the same. No change in proteolytic activities was seen in strain T1 with AgSD. Molecular mechanisms for these observations are discussed.

show abstract

An Evaluation of the Antibacterial Activities of Combinations of Sulfonamides, Trimethoprim, Dibromopropamidine, and Silver Nitrate Compared with Their Uptakes by Selected Bacteria

Cited by 46 publications

References 22 publications

Mechanism for Synergism between Sulphonamides and Trimethoprim Clarified

Mechanism for Synergism between Sulphonamides and Trimethoprim Clarified

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Effects of silver sulphadiazine on the production of exoproteins by Staphylococcus aureus

Contact Info

Product

Resources

About