An evaluation of pharmacotherapy for exercise-induced asthma

Anderson, Sandra D.; Seale, J. Paul; Ferris, L; Schoeffel, Robin E.; Lindsay, D. A.

doi:10.1016/0091-6749(79)90024-1

Cited by 134 publications

(33 citation statements)

References 38 publications

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“…Protection against exercise-induced bronchoconstriction has not been studied in such detail, particularly for early time points such as 5 and 30 min as in the present study. The magnitude of protection found was within the values reported for formoterol [5,6], salmeterol [11,12] and terbutaline [14,15] indicating that study conditions and subjects enrolled were similar to those of previous protocols. It also suggests that the observation of a similar protection for formoterol and salmeterol 5-30 min after inhalation fits with previous data using longer intervals of time.…”

Section: Discussionsupporting

confidence: 68%

Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline

Richter¹,

S²,

Jörres³

et al. 2002

European Respiratory Journal

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The onset of bronchoprotection as obtained by various b 2 -agonists has not been examined in a comparitive study. In this study, the onset of bronchodilation and protection against exercise-induced bronchoconstriction in asthmatics after inhalation of the long-acting b 2 -agonists formoterol and salmeterol and the shortacting b 2 -agonist terbutaline were measured.Twenty-five subjects with asthma and a history of exercise-induced bronchoconstriction (mean baseline forced expiratory volume in one second (FEV1): 90% predicted; mean fall in FEV1 after exercise: 31% from baseline) were enrolled in this double-blind, double-dummy, placebo-controlled, randomized, four-period crossover study. Exercise challenges were performed on 12 days at either 5, 30, or 60 min after inhalation of a single dose of formoterol (12 mg Turbuhaler1), salmeterol (50 mg Diskus1), terbutaline (500 mg Turbuhaler1) or placebo.Exercise-induced bronchoconstriction (maximum fall in FEV1 or area under the curve) did not differ significantly between terbutaline, formorerol and salmeterol either 5, 30, or 60 min after inhalation of the study medication. In contrast, the onset of bronchodilation was slower after salmeterol compared to terbutaline and formoterol (pv0.05, each), which both showed a similar time course. At all time points between 5 and 60 min, formoterol provided significantly greater bronchodilation than salmeterol (pv0.05).These data indicate that equipotent doses of the bronchodilators salmeterol, formoterol and terbutaline were similarly effective with respect to their short-term protective potency against exercise-induced bronchoconstriction, despite the fact that the time course of bronchodilation was significantly different between the three b 2 -agonists.

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Section: Discussionsupporting

confidence: 68%

Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline

Richter¹,

S²,

Jörres³

et al. 2002

European Respiratory Journal

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“…These children are often discouraged from physical activities for fear of breathlessness. The currently available beta 2 -adrenoceptor agonists by the inhaled route will prevent EIA in about 90% of patients when given prior to activity [1]. However, the duration of their protective effect is usually less than 2 h [2,3], probably because of the hydrophilic nature of these agents and their rapid clearance from the airways [4].…”

mentioning

confidence: 99%

Salmeterol in exercise-induced bronchoconstriction in asthmatic children: comparison of two doses

Benedictis¹,

Tuteri²,

Pazzelli³

et al. 1996

Eur Respir J

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S Sa al lm me et te er ro ol l i in n e ex xe er rc ci is se e--i in nd du uc ce ed d b br ro on nc ch ho oc co on ns st tr ri ic ct ti io on n i in n a as st th hm ma at ti ic c c ch hi il ld dr re en n: : c co om mp pa ar ri is so on n o of f t tw wo o d do os se es s Twelve children (aged 7-14 yrs) with asthma were studied in a double-blind, cross-over, placebo-controlled design. On three separate days, exercise tests were performed 1 h and 12 h after administration of the drug. Pulmonary function measurements were performed before drug inhalation, before every exercise test and 1, 5, 10, 15 and 30 min after the end of exercise. The response was expressed as maximal decrease in forced expiratory volume in one second (FEV1).Both doses of salmeterol provided significant bronchodilation for up to 12 h, with no difference between them. Maximal exercise-induced decrease in FEV1 (% fall) 1 h after pretreatment was (mean±SD) 35±16, 10±10 and 4±3% for placebo, 25 and 50 µg salmeterol, respectively. At 12 h after pretreatment these values were 31±14, 19±12 and 15±13%, respectively. Individual protection against exercise-induced bronchoconstriction at 1 and 12 h did not vary between the dosages (p<0.05), even though the protection obtained by 25 µg at 12 h was no longer significant versus placebo.We conclude that 25 µg of inhaled salmeterol provides equally effective long-lasting bronchodilation and acute protection against exercise-induced bronchoconstriction as 50 µg, and may be a suitable dose for most asthmatic children.

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“…BALF cell profile data also suggest that challenge with warm, wet air [10,11,13], and pretreatment with β-agonists [14,15], attenuate AIB and significantly protect the canine mucosa from airway desiccation, when compared to untreated dry air challenged segments. In addition to β-agonists [14][15][16], methylxanthines [16,17], muscarinic receptor antagonists [13,18], cyclo-oxygenase inhibitors [11,13,19], leukotriene antagonists [20,21], and airway cooling [6][7][8][9] reduce or abolish AIB in canine peripheral airways and individuals with asthma.…”

mentioning

confidence: 99%

Dry air- and hypertonic aerosol-induced bronchoconstriction and cellular responses in the canine lung periphery

Freed¹,

Omori

Wc³

et al. 1994

Eur Respir J

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D Dr ry y a ai ir r--a an nd d h hy yp pe er rt to on ni ic c a ae er ro os so ol l--i in nd du uc ce ed d b br ro on nc ch ho oc co on ns st tr ri ic ct ti io on n a an nd dc ce el ll lu ul la ar r r re es sp po on ns se es s i in n t th he e c ca an ni in ne e l lu un ng g p pe er ri ip ph he er ry y We compared airflow-and hypertonic aerosol-induced bronchoconstriction (AIB and HIB, respectively) in the canine lung periphery, using a wedged bronchoscope to measure collateral system resistance (Rcs). Bronchoalveolar lavage (BAL) was used to examine changes in cells and mediators during AIB and HIB.We found that: 1) peripheral airways are not refractory to either dry air or hypertonic aerosols, and do not exhibit cross-refractoriness to these stimuli; 2) differences in strength of stimulus can alter the magnitude but not the time course of HIB; 3) within an individual, AIB and HIB are significantly correlated; 4) epithelial cells recovered in BAL fluid (BALF) are significantly elevated after AIB, and are similarly increased after HIB; 5) when compared to control, mediators recovered in BALF are significantly elevated after AIB but not HIB; 6) HIB is not altered by cyclo-oxygenase inhibition; and 7) lavage with hypertonic fluid does not affect the number of epithelial cells recovered, although the concentrations of some mediators are increased.We speculate that differences in cell and mediator profiles reflect differences in the time course of AIB and HIB that result from the modulation of temperature sensitive pathways that occurs during dry air, but not during hypertonic aerosol challenge.

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An evaluation of pharmacotherapy for exercise-induced asthma

Cited by 134 publications

References 38 publications

Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline

Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline

Salmeterol in exercise-induced bronchoconstriction in asthmatic children: comparison of two doses

Dry air- and hypertonic aerosol-induced bronchoconstriction and cellular responses in the canine lung periphery

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