An evaluation of paper chromatography for measuring the levels of radiochemical impurities in ^99mTc Medronate Injection

Determination of the radiochemical purity of 99mTc medronate injection by thin layer chromatography on iTLC‐SG: effect of medronate concentration on the value measured

“…Paper chromatography was performed on 25 × 190 mm strips of 54SFC chromatography paper (Whatman, Maidstone, UK) . The sample spot was applied to the origin, 25 mm from the bottom of the strip.…”

“…GMCP‐SA was shown to be suitable for most but not for 99m Tc medronate. In a subsequent investigation, 54SFC chromatography paper from Whatman was shown to be a suitable stationary phase for measuring the RCP of 99m Tc medronate …”

An evaluation of paper chromatography for measuring the levels of radiochemical impurities in 99mTc Medronate Injection

“…In a previous study, we attempted to address this situation by investigating the use of Varian's Glass Microfibre Chromatography Paper impregnated with salicic acid (GMCP‐SA) as a replacement for ITLC‐SG 2. Our results showed that this alternative is suitable for measuring the radiochemical impurities in all the 99m Tc radiopharmaceuticals investigated with the exception of 99m Tc Medronate.…”