An evaluation of low molecular weight heparin and hyperbaric oxygen treatment in the prevention of intra-abdominal adhesions and wound healing

Arıkan, Soykan; Adaş, Gökhan; Barut, Gul; Toklu, Akın Savaş; Kocakuşak, Ahmet; Uzun, Hafize; Kemik, Özgür; Daduk, Yildiray; Aydın, Seval; Pürisa, Sevim

doi:10.1016/j.amjsurg.2004.11.002

Cited by 49 publications

(41 citation statements)

References 28 publications

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“…20 Fortunately recent studies have revealed that minidose or low molecular weight heparins may reduce postoperative adhesions without an increase in complication rates. 21,22 Thus, different doses of heparin may deserve to be readdressed as an antiadhesive product in detailed investigations particularly in reducing the side effects, such as bleeding.…”

mentioning

confidence: 99%

Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

Bahadir¹,

Öncel²,

Kement³

et al. 2007

Diseases of the Colon &Amp; Rectum

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mentioning

confidence: 99%

Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

Bahadir¹,

Öncel²,

Kement³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…21 had a similar study. They applied 1mgr/kg enoxaparin per day for seven days on abdominal wound healing.…”

Section: Discussionmentioning

confidence: 74%

Comparison of effects of unfractionated heparin and low molecular weight heparin on skin wound healing of rats

et al. 2012

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PURPOSE:To compare the effects of unfractionated heparin (UH) and a low molecular weight heparin (LMWH) on skin wound healing of rats. METHODS: Forty eight male Sprague-Dawley rats underwent 8mm full thickness dorsal skin wounds and were randomly assigned to three equal groups. In experimental group A, heparin sodium was injected at a concentration of 1000U/kg. In experimental group B, enoxaparin was injected at a concentration of 1mg/kg. Physiologic saline (0.5ml) was administered to the control group. Injections were made subcutaneously, once daily, for seven days. At 7 th and 10 th days tissue samples were taken from all rats. Histologic examination of these tissues was made under light microscope and scored. RESULTS: Histological examination showed a significant difference between the 7 th and 10 th day groups in wound healing. It was observed that wound healing of LMWH injected group is better. This difference is statistically significant at 10 th day. CONCLUSIONS: Daily administration of single doses of unfractionated heparin and a low molecular weight heparin improves wound healing positively. Low molecular weight heparin induces wound healing more than unfractionated heparin.

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“…Numerous articles on the combination of some agents used adhesion prevention have been published but knowledge on this subject is limited and contradictory [17,18,[29][30][31] . Şahin and Sağlam [19] researched heparin to the carboxymethylcellulose at laparotomy, whereas Başbuğ et al [20] added hyaluronic acid plus heparin, Tayyar et al [26] tried heparin to the amniotic membrane to cover injured rabbit uterine horns.…”

Section: Discussionmentioning

confidence: 99%

“…These combinations seem to be more effective in reducing adhesion formation rather than the use of heparin, hyaluronic acid, carboxymethylcellulose and amniotic membrane alone. Conversely, some researchers [17,27,[29][30][31][32] revealed that there was no difference between the groups in the combined application of various drugs (HA/CMC+atorvastatin, dimethyl sulfoxide+synovial fluid, low molecular weight heparin+hyperbaric oxygen, medroxyprogesterone acetate+heparin, HA/CMC+vitamin E, vitamin E+selenium) on the prevention of intraabdominal adhesions.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Köm¹

2013

Kafkas Univ Vet Fak Derg

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Despite the development in the knowledge concerning pathophysiology of abdominal cavity and improvement in surgical techniques, intraabdominal adhesions are one of the most common complications in surgery. The aim of this study was to determine the effects of hyaluronic acid/carboxymethylcellulose (HA/CMC) and flunixin meglumine combination on the prevention of postoperative intraabdominal adhesions in rabbits. All the surgery were made under aseptic condition under general anesthesia. A 2x2 cm area of parietal peritoneum was resected on the abdominal wall after median laparotomy. Twenty-four adult, male rabbits were divided into four groups equally. Groups were evaluated as C (control), S (HA/CMC), F (flunixin meglumine), and SF (HA/CMC and flunixin meglumine combination). No medication was given to the rabbits in group C. In S and SF groups, 3x3 cm of HA/CMC applied directly to peritoneal defect. In F and SF groups, flunixin meglumine was administred 1.1 mg/kg for 5 days intraperitoneally. Relaparotomy was performed 10 days after surgery. As a result of macroscopical and histopathological evaluations, the scores of adhesion in the S, F, and SF groups were significantly lower than those of the control group (P<0.05). Adhesion scores in SF group were lower as compared to S and F groups (P<0.05). It is observed that HA/CMC and flunixin meglumine combination can be used more effective on the prevention of postoperative intraabdominal adhesions in rabbits.

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An evaluation of low molecular weight heparin and hyperbaric oxygen treatment in the prevention of intra-abdominal adhesions and wound healing

Cited by 49 publications

References 28 publications

Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

Comparison of effects of unfractionated heparin and low molecular weight heparin on skin wound healing of rats

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

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