An Evaluation of<i>Echinacea angustifolia</i>in Experimental Rhinovirus Infections

Turner, Ronald B.; Bauer, Rudolf; Woelkart, Karin; Hulsey, Thomas C.; Gangemi, J. David

doi:10.1056/nejmoa044441

Cited by 200 publications

(141 citation statements)

References 19 publications

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“…9 A subsequent large, high-quality randomized controlled trial found no benefit of Echinacea angustifolia for the treatment of experimentally induced rhinovirus infection. 10 However, some authorities believe that a different species (Echinacea purpurea) or a higher dose of the species studied, would have been more likely to find an effect. 11 The herb is believed to be safe, with prior studies showing rates of side effects similar in Echinacea and placebo groups.…”

Section: Efficacymentioning

confidence: 99%

“…The most critical element will be to define specific standards for herbal products to ensure consistency between studies. Even recent studies (including the aforementioned study of Echinacea) 10 that used highquality methodology were open to criticism about the formulation of the herbal product used because no clear, wellestablished standard of the chemical fingerprint exists for most commonly used herbs. The effort to create standards for herbal products is most likely to be successful if supported and coordinated by an appropriately funded branch of the FDA.…”

Section: Future Directionsmentioning

confidence: 99%

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Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation

2008

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Section: Efficacymentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation

2008

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“…However, data are in conflict regarding its efficacy, with some studies supporting effectiveness (Goel et al 2005;Lindenmuth and Lindenmuth 2000;Schulten et al 2001) and others discounting it (Barrett et al 2002;Turner et al 2005;Yale and Liu 2004).…”

Section: Introductionmentioning

confidence: 99%

Phenetic Comparison of Seven Echinacea Species Based on Immunomodulatory Characteristics

et al. 2006

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The purpose of the present investigation was to compare similarities and differences in immune response among Echinacea species, which are commonly used to treat upper respiratory infections. The investigation involved two components: acquisition of immunomodulatory data reported here for the first time, and combined phenetic analysis of these data along with previous reports. Experimental data were obtained by stimulating human PBMC in vitro with extracts from Echinacea spp. and assaying production of three cytokines (interleukin-1β [IL-1β], interleukin-2 [IL-2], and tumor necrosis factor-α [TNF-α]). Phenetic analyses were employed to compare responses across the entire data set, including UPGMA (Unweighted Pair Group Method with Arithmetic Mean) and neighbor-joining methods. In the immune experiments conducted for this investigation, E. angustifolia, E. paradoxa, E. purpurea, E. simulata, and E. tennesseensis extracts significantly augmented IL-1 β and TNF-α production, whereas no extracts significantly modulated IL-2. All phenetic methods produced similar dendrograms, revealing two species pairs (E. angustifolia + E. simulata and E. pallida + E.sanguinea) where both species cluster tightly and have similar immune-response profiles. These two species-pairs are maximally dissimilar from each other. The remaining species (E. paradoxa, E. purpurea, and E. tennesseensis) occupy intermediate positions in the dendrogram. Our results suggest that Echinacea spp. act heterogeneously on immune function. The utility of these data for science and industry is discussed.

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“…Kesimpulan penelitian yang sama juga ditemukan pada penggunaan echinaceae dalam terapi rhinitis. [13][14][15][16] Lima koma tujuh persen orang tua memberikan jamu tradisional seperti tolak angin anak, jeruk nipis dan kecap, serta beras kencur. Kandungan dalam 17 Kandungan madu sendiri terbukti dapat mengurangi gejala batuk dan memperbaiki kualitas tidur anak pada malam hari.…”

Section: Pembahasanunclassified

Profil Penggunaan Obat Batuk Pilek Bebas Pada Pasien Anak di Bawah Umur 6 Tahun

Soedibyo

Yulianto

Wardhana

2016

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B atuk pilek merupakan penyakit yang menyerang baik anak maupun dewasa. Pada anak, batuk pilek banyak terjadi pada usia di bawah 6 tahun. Rata-rata setiap anak mengalami 6 hingga 8 kali keluhan setiap tahunnya. Batuk pilek sebagian besar disebabkan oleh rhinovirus, adenovirus, virus influenza, enterovirus, RSV, dan coronavirus. 1Obat over the counter (OTC), atau obat yang dijual bebas untuk keluhan batuk pilek, banyak digunakan oleh orang tua untuk mengatasi keluhan batuk pilek, banyak tersedia untuk anak dengan berbagai macam kombinasi. Obat batuk pilek yang beredar tersebut, Soepardi Soedibyo, Arie Yulianto, WardhanaDepartemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia/RS Dr. Cipto Mangun Kusumo, Jakarta Latar belakang. Obat batuk pilek over the counter (OTC) banyak digunakan secara luas oleh orang tua untuk mengatasi keluhan batuk pilek pada anak. American Academy of Pediatrics (AAP) merekomendasikan untuk tidak menggunakan obat batuk pilek yang dijual bebas pada anak usia di bawah 6 tahun oleh karena belum sepenuhnya teruji efektivitasnya pada anak, bahkan terdapat risiko efek samping berbahaya. Tujuan. Mengetahui profil penggunaan obat batuk pilek OTC oleh orang tua pada anak usia di bawah 6 tahun di Puskesmas Kelurahan Pegangsaan, Jakarta. Metode. Penelitian deskriptif (survei) dengan teknik wawancara menggunakan kuesioner pada semua orang tua pasien yang membawa anak sakit berumur di bawah 6 tahun di Puskesmas kelurahan Pegangsaan dalam periode 17 Oktober 2011 sampai 04 November 2011. Pengambilan sampel dilakukan secara konsekutif. Hasil. Didapatkan 106 responden penelitian, 82,1% orang tua memberikan obat batuk pilek OTC dengan alasan supaya anak cepat sembuh (47,2%). Kandungan obat batuk pilek OTC yang digunakan adalah klorfeniramin maleat (58,8%), parasetamol (56,5%), gliceryl guaicolate (50,6%), pseudoefedrin (28,2%), dextromethorphan (22,4%) dan bromhexine (9,4%). Efek samping obat dirasakan pada 31% responden, dan gejala terbanyak adalah mengantuk (85%). Kesimpulan. Sebagian besar orang tua memberikan obat batuk pilek OTC apabila anaknya sakit. Komposisi kombinasi obat OTC yang banyak digunakan adalah klorfeniramin maleat, parasetamol, gliceryl guaicolate, pseudoefedrin, dextromethorphan dan bromhexine. Efek samping mengantuk yang terbanyak dirasakan oleh subjek. Sari Pediatri 2013;14(6):398-404.

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An Evaluation ofEchinacea angustifoliain Experimental Rhinovirus Infections

Abstract: The results of this study indicate that extracts of E. angustifolia root, either alone or in combination, do not have clinically significant effects on infection with a rhinovirus or on the clinical illness that results from it.

Cited by 200 publications

References 19 publications

Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation

Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation

Phenetic Comparison of Seven Echinacea Species Based on Immunomodulatory Characteristics

Profil Penggunaan Obat Batuk Pilek Bebas Pada Pasien Anak di Bawah Umur 6 Tahun

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