An evaluation of corneal nerve morphology and function in moderate keratoconus

Laser scanning in vivo confocal microscopy and quantitative aesthesiometry reveal decreased corneal innervation and sensation in keratoconus

“…12 However, although a previous quantitative analysis of corneal nerves in moderate keratoconus demonstrated significantly reduced sub-basal nerve density in contact lens wearing keratoconic subjects compared with contact lens wearing controls, unlike the current study, there was no significant difference in sub-basal nerve density in the non-contact lens wearing subjects in the keratoconus and control groups. 9 This latter difference may be due to the smaller number of subjects in the previous study.…”

“…7 The lack of association between these parameters in the current study may be attributed to the small sample size and the differences in severity group sizes. In a more recent study by Simo Mannion et al, 9 subjects with keratoconus who wore contact lenses had significantly lower corneal sensation compared to normal controls who wore contact lenses. The differences between the results of previous studies and the current one may be attributed to the different methods of assessing corneal sensitivity.…”

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma

“…[13][14][15][16][17][18] Furthermore, a positive association between corneal nerve regeneration and corneal sensitivity has been observed after penetrating keratoplasty and laser refractive surgery. [19][20][21] Rosenberg et al 27 have reported that reduction of subbasal plexus nerve fibers correlates with loss of corneal sensitivity in patients with diabetic neuropathy, while tortuosity of subbasal nerves correlated significantly with the severity of diabetic neuropathy.…”

“…[10][11][12] Moreover, the architecture of the corneal subbasal nerve plexus has been investigated, with the aid of confocal microscopy, in patients with keratoconus, Sjogren syndrome, or dry eye, as well as after penetrating keratoplasty, laser in situ keratomileusis, or photorefractive keratectomy. [13][14][15][16][17][18][19][20][21] Within this context, the purpose of this study was to investigate the corneal sensitivity in patients with PCG and correlate the clinical findings with the corneal subbasal nerve density by use of LSCM.…”

A fully automatic nerve segmentation and morphometric parameter quantification system for early diagnosis of diabetic neuropathy in corneal images

“…Corneal Confocal Microscopy (CCM) is a rapid non-invasive in vivo clinical technique for capturing images of the different corneal layers [2]. Morphological alterations in the epithelium, stroma and endothelium provide insights into a variety of corneal diseases [3,4] and assessment of the effects of wearing contact lenses [1], LASIK or PRK [5], fungal keratitis [6], corneal transplantation [7] or conditions such as keratoconus [8,9]. CCM has also been used in the assessment of peripheral neuropathies [10,11,12,13,14,15,16,17,18,19].…”