An estrogen modulated protein in rabbit oviducal fluid

Evidence of a uteroglobin-like protein in epithelial cells of reproductive and non-reproductive tissues of the rabbit

“…Johnson (1972) and Kirchner (1972Kirchner ( , 1976 have used an antiserum specific to uteroglobin and reported specific fluorescent staining patterns in uterine tissue sections of pregnant and oestrous rabbits. Kay & Feigelson (1972) have described a protein in the rabbit oviduct that was estimated to have a molecular weight of 18 000, similar to that of the protein in the uterus of pregnant animals. Furthermore, they reported that the protein in the oviduct exhibits a cone-like structure upon electrophoretic destaining in the disc-gel-electrophoresis system.…”

Purification of human alpha uterine protein

“…Although this conclusion has been disputed by Maurer & Beier (1976), blastokinin may still have some indirect embryotrophic effect, perhaps associated with its postulated role as a progesterone carrier (Beier, 1976;Beato, 1977). Despite higher initial estimates by Krishan & Daniel (1968), the molecular weight of blastokinin is now accepted to be approximately 15 000 by gel filtration (Kay & Feigelson, 1972;Daniel, 1976). It is not clear whether a blastokinin also exists in the human uterus.…”

Binding of uteroglobin to microsomes and plasmatic membranes

“…In the rabbit, the main source of UG is the endometrial epithelium where its gene can be induced by progesterone in early pregnancy. The protein is also synthesized in the lung [3], the epidydimis [4] and the oviduct [5] under the control of glucocorticoids, androgens and estrogens, respectively. In other mammalian species, the counterpart of UG has been called CC10 (for lung Clara cell 10 kDa protein), although both proteins are very similar on the basis of amino acid sequence, quaternary structure, tissue expression and the organization of their genes.…”