An estimation of the effect of mono/poly-hydroxy organic compounds on the interaction of tetradecyltrimethylammonium bromide with levofloxacin hemihydrate antibiotic drug

Measurements of density, speed of sound, conductivity, and fluorescence spectroscopy have been carried out to study the interactions between cationic surfactant cetyltrimethylammonium bromide in an aqueous solution of the fluoroquinolone drug at different concentrations and temperatures. Volumetric and compressibility parameters, such as apparent molar volumes (V φ ), isentropic compressibility (κ s ), and apparent molar isentropic compressibility (κ φ, s ), have been obtained from density and speed of sound. The critical micelle concentration (CMC) of cetyltrimethylammonium bromide (CTAB) is found to decrease with an increase in [antibiotic drug] and increase with an increase in temperature, accounting for the fact that hydrophilic dehydration plays a decisive role for micellization to take place. The various thermodynamic parameters indicate the spontaneity of micellization in the presence of drug moiety. The CMC values have been calculated using pyrene as a fluorescent probe at room temperature, and a good qualitative correlation is found to exist well with the CMC values determined using speed of sound and conductivity measurements.

Section: Introductionmentioning

confidence: 99%

Modulation in Aggregation Behavior of Cationic Surfactant in Presence of Fluoroquinolone Drug: A Physicochemical Approach

Pathania

Chauhan

2020

“…The conductivity meter was calibrated each time prior to its application through KCl having certain concentration. The conductivity measurement of all solutions was performed following the procedure reported in the literature (Amin et al, ; Hoque et al, ; Mahbub et al, , , , ). Stock solutions (25 mmol kg −1 ) of TTAB in aqueous/electrolyte medium had been constructed in the presence of CFH and inchmeal added to the corresponding solvent at a certain temperature.…”

Section: Methodsmentioning

confidence: 99%

Influence of Different Additives on the Interaction of Quinolone Antibiotic Drug with Surfactant: Conductivity and Cloud Point Measurement Study

Rahim

Mahbub

Islam

et al. 2019

Self Cite

Conductometric and cloud point (CP) measurement studies have been performed to investigate the interaction of tetradecyltrimethylammonium bromide (TTAB) and Triton® X‐100 (TX‐100) with ciprofloxacin hydrochloride (CFH) in different solvents over the temperature range of 295.15–315.15 K. CFH is used for the treatment of various bacterial infections. The observed critical micelle concentration (CMC) values of TTAB were found to be reduced in the presence of electrolytes (Na2SO4/Na3PO4), and this reduction proceeds with the elevation of salt concentration. The order of the CMC of TTAB follows the trend: cmcH2normalO > cmcNa3PO4 >cmcNa2SO4. The observed CMC values of TTAB were found to increase with increasing temperature and decrease with increasing concentration of CFH in aqueous medium. The values of Gibbs free energy of micellization (∆Gmo) for the TTAB/TTAB + CFH mixture were found to be negative, implying spontaneous micellization. The estimated CP of TX‐100 decreases with increasing concentration of TX‐100 in aqueous medium. The CP values first decrease with increasing concentration of CFH and then increase at higher concentration of CFH almost in all cases investigated. The values of free energy of clouding were found to be positive in all cases studied implying that phase separation of TX‐100 was nonspontaneous. The other thermodynamic parameters associated with the micellization of TTAB and the phase separation of TX‐100 were estimated and explained.

“…The dehydration of hydrophilic headgroups favors the micellization process, i.e., CMC values decrease. On the other hand, a decrease of hydrophobic hydration of monomeric CTAB prohibits the extent of micellization, i.e., CMC values increase (Amin et al, 2018;Hoque et al, 2018). The first effect is dominant at a lower temperature, while the second one is governed at a higher temperature.…”

Section: Influence Of Temperature On the Micellization Behavior Of Armentioning

confidence: 99%

“…Usually, the degree of solubilization of amphiphilic molecules is enhanced with the increase of temperature, which is the outcome of increased thermal motion that results in the increase of solubilization. This effect disfavors micellization and therefore CMC increases with temperature (Amin et al, 2018;Hoque et al, 2018). There is also a possibility for the formation of strong dye-surfactant ion pairs (Mahbub et al, 2019e).…”

Section: Influence Of Temperature On the Micellization Behavior Of Armentioning

confidence: 99%

Influence of Additives and Temperature on the Interaction of Acid Red 151 Dye with Cetyltrimethylammonium Bromide: A Conductometric Study

Nur

Mahbub

Rahman

et al. 2020

Self Cite

The interaction of an anionic textile dye, acid red 151 (AR), with a cationic surfactant, cetyltrimethylammonium bromide (CTAB), in aqueous electrolyte medium (e.g., KCl, NaCl) and in H2O + ethanol medium was observed using the conductometric method. Two critical micelle concentrations (CMC) were found for the AR + CTAB system in water and H2O + ethanol medium, but only one CMC was detected for AR + CTAB in salt+H2O media and for pure CTAB in all solutions. The change in CMC behavior of CTAB in the presence of AR indicates the occurrence of strong interaction between AR and CTAB. The extent of solubility increases with an increase of temperature, which disfavors micellization. The CMC values in NaCl solution are comparatively lower than those found in KCl solution, which signifies that the micelle formation is more favorable in attendance of NaCl. In aqueous ethanol solution, two CMC values were also observed for AR + CTAB that are higher than those obtained in water. The free energy of micellization (∆Gm0) was negative, which illustrates a thermodynamically spontaneous micellization process. The values of enthalpy (∆Hmo) and entropy (∆Smo) of micellization show that the process was entirely entropically driven at a lower temperature; but, enthalpic events are favored at elevated temperature in electrolyte medium, whereas both enthalpy and entropy are reduced in attendance of ethanol. In aqueous medium, the thermodynamic parameters signify the presence of electrostatic interaction between AR and CTAB at higher temperatures, while the hydrophobic interaction is the main driving force at a lower temperature. A linear expression of ∆Hmo as a function of ∆Smo demonstrates enthalpy‐entropy compensation over the experimental conditions employed in this study.