An ESR-Study of the Peroxidation of Lecithin Multilayers

Abstract

By m eans of a set of fatty acid and fatty acid ester spinlabels we found th at spo n tan eo u s pero x id atio n of lecithin m ultilayers increases the rigidity of all regions of the lipid bilayer. H ow ever the p a rtitio n coefficient of T E M P O increased with peroxidation indicating a g reater affinity of T E M P O to the m odified bilayer.

Structural changes of proteins in fish red blood cells after copper and mercury treatment

“…The decrease of the motion parameter h+~/ho of two spin label fatty acids located at different depths within the lipid bilayer indicates the lowering of membrane fluidity in copper-or mercury-treated erythrocytes. These results are in agreement with the observation that lipid peroxidation produces the decrease of liposome fluidity (Bartosz et al 1987). Nevertheless, we were unable to find lipid peroxidation products (TBARS -thiobarbituric acid reactive substances) in copper-treated erythrocytes (Gabryelak and Gwozdzinski, 1987).…”

Effect of Hyperthermia and Lipid Peroxidation on the Erythrocyte Membrane Structure

“…There is a puzzling controversy concerning the modification of the physical properties of membranes by lipid peroxidation . Most workers have found that lipid peroxidation increases membrane rigidity (Bartosz et al 1987, LeBel et al . 1989, Masotti et al 1989, Ohyashiki and coworkers 1986, Richter 1987 fluidity to result from membrane lipid peroxidation (Bailly and co-workers 1989, Delmelle 1978, Grzelinska et al .…”