An eruption of yellow-red papules on the trunk, arms, and legs of an adult

Multiple xanthogranulomas in an adult patient: clinical, dermoscopic, reflectance confocal microscopy and histopathological features

“…PLD and RCM are useful tools for the in vivo diagnosis of XG 7–12. In our case, the dermoscopy and RCM features were similar to those reported in single lesions of XG 7–12.…”

“…PLD and RCM are useful tools for the in vivo diagnosis of XG 7–12. In our case, the dermoscopy and RCM features were similar to those reported in single lesions of XG 7–12. The homogeneous orange-yellowish hue seen at dermoscopy is related to the histopathological presence of foamy histiocytes and Touton giant cells; the last typically appear at RCM as peculiar giant cells surrounded by highly refractive ring due to the cytoplasm rich of lipids.…”

Adult-onset xanthogranuloma

“…Characteristic histologic findings in AXG are: foamy histiocytes in the dermis, variable presence of Touton giant cells, which are multinucleated, with homogeneous eosinophilic cytoplasmic center and xanthomatization in the periphery [4]. Immunohistochemical stains are typically positive for anti-CD68, factor XIIIa, and often anti-CD14.…”