An Epidemiological Study of Workers Producing Enzyme Washing Powders

Newhouse, Muriel L.; Tagg, Beryl; Pocock, S. J.; McEwan, A.C.

doi:10.1016/s0140-6736(70)90924-4

Cited by 122 publications

(31 citation statements)

References 7 publications

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“…This wide range is probably related to the degree of ex posure to the enzyme. Workers involved in preparing enzyme mixes or adding enzyme to detergent base have the highest risk of sensitization with subsequent development of respiratory disease [26]. Atopy has been re ported by some investigators to predispose individuals to sensitization [11,26] while others report no difference in the frequency of sensitiza tion between atopic and nonatopic workers [25].…”

Section: Introductionmentioning

confidence: 99%

Influence of Detergent on Aerosol Allergic Sensitization with Enzymes of <i>Bacillus subtilis</i>

Markham¹,

Wilkie²

1976

Int Arch Allergy Immunol

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An anionic detergent, sodiumdodecylbenzenesulphonate, had an adjuvant effect upon aerosol allergic sensitization with subtilopeptidase A, a proteolytic enzyme of Bacillus subtilis. Both local and systemic antibody responses were accelerated and prolonged by use of the detergent. This adjuvant effect was only seen when an inactive form of the enzyme was used. The detergent, however, was able to potentiate early clinical responses upon initial exposure to the active enzyme.

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Section: Introductionmentioning

confidence: 99%

Influence of Detergent on Aerosol Allergic Sensitization with Enzymes of <i>Bacillus subtilis</i>

Markham¹,

Wilkie²

1976

Int Arch Allergy Immunol

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“…After that, a number of epidemiologic industry studies revealed high allergy prevalence among workers occupationally exposed to proteases, which in less than 10 years made it necessary to enact regulations on recommended safety procedures. Some producers even ceased using enzymes, and some employers began taking up "prophylactic steps" decided to exclude atopic workers from detergents processing 4,10,11) . As a consequence of widespread improvement in the industrial hygiene, the problem of enzyme-induced airway sensitization seemed to have disappeared 12,13) .…”

Section: Discussionmentioning

confidence: 99%

Occupational Asthma in Female Factory Worker Resulting from Exposure to Savinase in Dishwashing Tablets—A Case Study

Lipińska‐Ojrzanowska

Świerczyńska-Machura

Tymoszuk

et al. 2013

Journal of Occupational Health

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Occupational Asthma in Female Factory Worker Resulting from Exposure to Savinase in Dishwashing Tablets—A Case Study: Agnieszka LIPIŃSKA‐OJRZANOWSKA, et al. Department of Occupational Diseases, Nofer Institute of Occupational Medicine, Poland— Objectives Savinase is one of the endopeptidases widely used in washing detergents. Its ability to cause respiratory allergy has been known. Up to now, most cases of occupational asthma (OA) to savinase have been described among workers involved in the manufacture of laundry detergents. We present a case study of 51‐year‐old female worker of a dishwashing tablets factory, who had been packaging readymade tablets into foil wrappers for 4 years and developed respiratory symptoms, such as cough, dyspnoea and wheezing. Methods A number of clinical procedures were performed, including the clinical examination, routine laboratory tests, evaluation of total and allergen‐specific serum IgE (asIgE) to enzymes, skin prick tests for common allergens, rest spirometry, inhalation methacholine challenge test and a single‐blind, placebo‐controlled specific inhalation challenge test (SICT) with dishwashing tablets. Results Clinical findings and results of routine laboratory tests were within normal limits. Baseline nonspecific bronchial hyperreactivity was revealed. In patient's serum blood we found significantly elevated as IgE to savinase. Decline of FEV1 and PEF in late phase of asthmatic reaction was observed during the specific challenge test. The patient reported chest tightness between 5−12 hours after exposure to dishwashing tablet ingredients. Cytological assessment of an induced sputum revealed increase in the percentage of eosinophils 24 hours after specific challenge in comparison to values noted before the SICT. Conclusions Positive clinical response to the challenge confirmed in objective method tests validated the diagnosis of OA.

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“…13,14 This antigen must have been macromolecular in size because a compound with molecular weight of less than 6 kD was excluded by the dialysis membrane which we used. The patient had atopy and showed positive immediate responses to common inhalant allergens in our environment.…”

Section: Discussionmentioning

confidence: 99%

Occupational asthma and IgE sensitization to cellulase in a textile industry worker

Nahm

Park

Choi

1999

Annals of Allergy, Asthma & Immunology

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An Epidemiological Study of Workers Producing Enzyme Washing Powders

Cited by 122 publications

References 7 publications

Influence of Detergent on Aerosol Allergic Sensitization with Enzymes of <i>Bacillus subtilis</i>

Influence of Detergent on Aerosol Allergic Sensitization with Enzymes of <i>Bacillus subtilis</i>

Occupational Asthma in Female Factory Worker Resulting from Exposure to Savinase in Dishwashing Tablets—A Case Study

Occupational asthma and IgE sensitization to cellulase in a textile industry worker

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