An epidemiological study of brucellosis on mainland China during 2004–2018

Wang, Yu; Zhang, Lina; Wang, Anping; Yu, Yifeng; Chen, Yingyu; Li, Xiang; Robertson, Ian D.

doi:10.1111/tbed.13896

Cited by 25 publications

(30 citation statements)

References 37 publications

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“…Shaanxi Province is in the centre of northern China and includes Inner Mongolia, Gansu, Ningxia, and Shanxi; these nearby provinces have all reported a high prevalence of brucellosis, and the epidemic in human brucellosis peaked later than in the northern provinces. Although the annual average incidence rate (2.48/100,000) of human brucellosis in this region is significantly lower than that in other northern regions 20 , the epidemiological features have obviously changed. The county numbers of reported cases increased from 36 in 2008 to 84 in 2020.…”

Section: Discussionmentioning

confidence: 73%

Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Chen

Liu

Nie

et al. 2021

Sci Rep

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In the present study, surveys of case numbers, constituent ratios, conventional biotyping, and multilocus sequence typing (MLST) were applied to characterize the incidence rate and epidemiological characteristics of human brucellosis in Shaanxi Province, China. A total of 12,215 human brucellosis cases were reported during 2008–2020, for an annual average incidence rate of 2.48/100,000. The most significant change was that the county numbers of reported cases increased from 36 in 2008 to 84 in 2020, with a geographic expansion trend from northern Shaanxi to Guanzhong, and southern Shaanxi regions; the incidence rate declined in previous epidemic northern Shaanxi regions while increasing each year in Guanzhong and southern Shaanxi regions such as Hancheng and Xianyang. The increased incidence was closely related to the development of large-scale small ruminants (goats and sheep) farms in Guanzhong and some southern Shaanxi regions. Another significant feature was that student cases (n = 261) were ranked second among all occupations, accounting for 2.14% of the total number of cases, with the majority due to drinking unsterilized goat milk. Three Brucella species were detected (B. melitensis (bv. 1, 2, 3 and variant), B. abortus bv. 3/6, and B. suis bv. 1) and were mainly distributed in the northern Shaanxi and Guanzhong regions. Three known STs (ST8, ST2, and ST14) were identified based on MLST analysis. The characteristics that had not changed were that B. melitensis strains belonging to the ST8 population were the dominant species and were observed in all nine regions during the examined periods. Strengthened human and animal brucellosis surveillance and restriction of the transfer of infected sheep (goats) as well as students avoiding drinking raw milk are suggested as optimal control strategies.

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Section: Discussionmentioning

confidence: 73%

Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Chen

Liu

Nie

et al. 2021

Sci Rep

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“…A total of 524,980 human cases of brucellosis with an average annual incidence of 2.6 cases per 100,000 residents were reported in mainland China for the period 2004–2018 (Wang et al., 2020). Similarly, the overall apparent seroprevalence of brucellosis in humans was 27.3% (95% CI: 23.7%–31.2%) in Mongolia (Zolzaya et al., 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Similar epidemiologic characteristics were found in Kazakhstan, where 75% of the newly diagnosed brucellosis cases were in the 10–39 age group, and 85.8% of the patients were rural residents (Shevtsova et al., 2019). People under 35 years of age are less likely to work in the livestock industries than those in the 36–54 age group, and people above 55 years in other regions of China (Wang et al., 2020).…”

Section: Discussionmentioning

confidence: 99%

Human brucellosis epidemiology in the pastoral area of Hulun Buir city, Inner Mongolia autonomous region, China, between 2003 and 2018

Liu

Wang³

et al. 2021

Transbounding Emerging Dis

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Human brucellosis represents a serious public health concern in Hulun Buir and requires a comprehensive epidemiologic analysis to define adapted control measures. The present study describes the case numbers, constituent ratios and incidence rate of human brucellosis. Conventional biotyping, that is abortus, melitensis, ovis and suis (AMOS)‐PCR and multi‐locus variable‐number tandem repeat analysis (MLVA) were used to characterize the Brucella strains. Between 2003 and 2018, a total of 23,897 human brucellosis cases were reported, with an incidence rate of 56.03/100,000, which is 20 times higher than the country's average incidence. This incidence rate increased year after year, culminating in 2005 and decreased between 2011 and 2018. Because Hulun Buir relies on a nomadic livestock rearing system, brucellosis spreads easily among different animal species and humans. In Xin Barag Left Banner and Xin Barag Right Banner, the incidence rates were, respectively, 226.54/100,000 and 199.10/100,000, exceeding those observed in other areas. Most of the cases occurred in the 25‐ to 45‐year‐old group, accounting for 65.74% of the cases (15,709/23,897), and among farmers, accounting for 66.71% (15,942/23,897). The male to female incidence ratio was 2.67:1. The higher incidence in younger people and the large gender ratio reflected the unique traditional production and lifestyle of nomads. Most reported cases were observed from April to June, indicating that more than 40% of the cases were related to the delivery of domestic livestock. The biotyping showed that the 44 isolated strains were all B. melitensis, including 12 Brucella melitensis biovar (bv) 1 and 32 B. melitensis bv. 3. The strains displayed a genetic similarity of 80%–100%. Our hypothesis is that human brucellosis outbreak in this region may be originating from a limited source of infection, so further investigation is necessary. The epidemic situation of human brucellosis in Hulun Buir is extremely serious, strengthened surveillance and control in animals’ brucellosis should be priority.

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“…HB is a major public health crisis in China. Although its true incidence remains largely unknown, it is conservatively estimated to vary from less than 0.03 to more than 160 individuals per 100,000 ( Pappas et al, 2006 ; Lai et al, 2017 ; Wang et al, 2020 ). It is important to have early detection and treatment of suspected cases.…”

Section: Discussionmentioning

confidence: 99%

Evaluating active versus passive sources of human brucellosis in Jining City, China

Sun

WenGuo

et al. 2021

PeerJ

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Human brucellosis (HB) remains a serious public health concern owing to its resurgence across the globe and specifically in China. The timely detection of this disease is the key to its prevention and control. We sought to describe the differences in the demographics of high-risk populations with detected cases of HB contracted from active versus passive sources. We collected data from a large sample population from January to December 2018, in Jining City, China. We recruited patients that were at high-risk for brucellosis from three hospitals and Centers of Disease Control and Prevention (CDCs). These patients were classified into two groups: the active detection group was composed of individuals receiving brucellosis counseling at the CDCs; the passive detection group came from hospitals and high-risk HB groups. We tested a total of 2,247 subjects and 13.3% (299) presented as positive for HB. The positive rates for active and passive detection groups were 20.5% (256/1,249) and 4.3% (43/998), respectively (p < 0.001). The detection rate of confirmed HB cases varied among all groups but was higher in the active detection group than in the passive detection group when controlled for age, sex, ethnicity, education, career, and contact history with sheep or cattle (p < 0.05). Males, farmers, those with four types of contact history with sheep or cattle, and those presenting fever, hyperhidrosis and muscle pain were independent factors associated with confirmed HB cases in multivariate analysis of the active detection group. Active detection is the most common method used to detect brucellosis cases and should be applied to detect HB cases early and avoid misdiagnosis. We need to improve our understanding of brucellosis for high-risk populations. Passive HB detection can be supplemented with active detection when the cognitive changes resulting from brucellosis are low. It is important that healthcare providers understand and emphasis the timely diagnosis of HB.

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An epidemiological study of brucellosis on mainland China during 2004–2018

Cited by 25 publications

References 37 publications

Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Human brucellosis epidemiology in the pastoral area of Hulun Buir city, Inner Mongolia autonomous region, China, between 2003 and 2018

Evaluating active versus passive sources of human brucellosis in Jining City, China

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