An epidemiologic study of irritable bowel syndrome in adolescents and children in South China: a school‐based study

Zhou, Huiqun; Li, D.; Gan, Cheng; Fan, Jian‐Gao; Lu, Huiqing

doi:10.1111/j.1365-2214.2010.01120.x

Cited by 37 publications

(46 citation statements)

References 9 publications

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“…A recent study using the Rome III criteria classified IBS patients as 20.1% constipation predominant, 18.5% diarrhea predominant, 10.3% alternating diarrhea and constipation, and 51.1% undetermined 8. In our study, constipation was also the most common subtype (42.3%), with diarrhea predominant in 33.3%, alternating attacks of both in 12.8%, and 11.5% unclassified.…”

Section: Discussionsupporting

confidence: 67%

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The Incidence of Irritable Bowel Syndrome in Children Using the Rome III Criteria and the Effect of Trimebutine Treatment

Karabulut

Beşer

Erginöz

et al. 2013

J Neurogastroenterol Motil

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Background/AimsIrritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders and when compared to the vast knowledge pertaining to adults with IBS, very little is known about IBS in children and adolescents. We aimed to explore the prevalence of IBS, identify symptoms and contributing factors and also to examine the efficacy of trimebutine maleate in children and adolescents.MethodsThe study involved 345 children and adolescents (4-18 years) and parents were requested to fill in a questionnaire, Rome III criteria was used to diagnose IBS. To exclude organic disease, all patients underwent medical investigations. Half of the randomly selected IBS patients were treated with trimebutine maleate while the rest of IBS patients were not. The IBS patients were reevaluated at the end of 3 weeks.ResultsThe prevalence of IBS according to Rome III criteria in children and adolescents was 22.6% and IBS with constipation was the predominant subtype. Back pain (OR, 6.68), headache (OR, 4.72) and chronic fatigue (OR, 3.74) were significantly higher in IBS group. The prevalence of IBS in both parents and depression in mothers was greater for the patient group than the healthy controls (P < 0.0001). The prevalence of functional dyspepsia in IBS group was 80.8% and was significantly higher than control group. Clinical recovery was seen in 94.9% of the trimebutine maleate group versus spontaneous recovery in 20.5% of the non-medicated group. The difference was significant (P < 0.0001).ConclusionsIBS is a common disorder in children and adolescents. IBS is closely associated with somatic and familial factors. Trimebutine maleate is effective for pediatric IBS patients.

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Section: Discussionsupporting

confidence: 67%

“…A recent Chinese survey of students determined that the prevalence of IBS in children and adolescents was 20.7% according to the Rome III criteria 8. In our study, the prevalence of IBS in children 4 to 18 years old was 22.6%, which is higher than that detected using the Rome I and II criteria.…”

Section: Discussioncontrasting

confidence: 59%

The Incidence of Irritable Bowel Syndrome in Children Using the Rome III Criteria and the Effect of Trimebutine Treatment

Karabulut

Beşer

Erginöz

et al. 2013

J Neurogastroenterol Motil

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“…The incidence of IBS in China is 5–20.72% [4, 5]. Clinical symptoms such as abdominal pain and diarrhea severely affect the quality of life for IBS patients.…”

Section: Introductionmentioning

confidence: 99%

Mild Moxibustion Decreases the Expression of Prokineticin 2 and Prokineticin Receptor 2 in the Colon and Spinal Cord of Rats with Irritable Bowel Syndrome

Zhou

Zhao

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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It has been proven that prokineticin 2 (PK2) and its receptor PKR2 play an important role in hyperalgesia, while mild moxibustion can relieve visceral hypersensitivity in a rat model of irritable bowel syndrome (IBS). The goal of the present study was to determine the effects of mild moxibustion on the expression of PK2 and PKR2 in colon and spinal cord in IBS rat model, which was induced by colorectal distension using inflatable balloons. After mild moxibustion treatment, abdominal withdrawal reflex (AWR) scores were assessed by colorectal distension; protein and mRNA expression of PK2 and PKR2 in rat colon and spinal cord was determined by immunohistochemistry and fluorescence quantitative PCR. Compared with normal rats, the AWR scores of rats and the expressions of PK2/PKR2 proteins and mRNAs in colon and spinal cord tissue were significantly increased in the model group; compared with the model group, the AWR scores of rats and the expressions of PK2/PKR2 proteins and mRNAs in colon and spinal cord tissue were significantly decreased in the mild moxibustion group. These findings suggest that the analgesia effect of mild moxibustion may be associated with the reduction of the abnormally increased expression of the PK2/PKR2 proteins and mRNAs in the colon and spinal cord.

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“…Therefore, 16 studies were included in the final analysis ( Fig. 1) (6,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). The total number of patients in these studies was 38,076.…”

Section: Literature Searchmentioning

confidence: 99%

“…They were conducted in Japan (n ¼ 2) (6,20), Korea (n ¼ 3) (19,21,28), China (n ¼ 6) (16,17,22,23,26,29), Iran (n ¼ 1) (27), Saudi Arabia (n ¼ 1) (24), and Sri Lanka (n ¼ 3) (1,18,25). One paper from Japan (20) reported data from 2 separate studies, and we could clearly identify prevalence of IBS in children and adolescents in both studies.…”

Section: Literature Searchmentioning

confidence: 99%

Gastrointestinal Manifestations in Diploid/Triploid Mixoploidy

Lalani

Elsner

Lebel

et al. 2015

J. pediatr. gastroenterol. nutr.

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A girl infant was delivered by cesarean section at 32 weeks of gestation because of growth arrest and poor movement patterns. The infant had feeding problems, which were based on gastroesophageal reflux, laryngomalacia, and decreased gut motility. Hypotonia was notable from the outset, and the patient eventually displayed significant delays in both motor and cognitive milestones. Meanwhile, lymphocytes had yielded a normal karyotype (46,XX), but at 2 years of age the patient underwent a skin biopsy and mosaicism because a 68,XX cell line was discovered in fibroblasts. At the age 6.4 years, the patient is short of stature below the 3rd percentile but has a weight at the 42nd percentile and head circumference above the 97th percentile. Other phenotypic features include low-set ears, piebald irides and scalp hair, eyelid ptosis, strabismus, broad nasal bridge, anteverted nares, upswept eyebrows, hypoplastic teeth, pectus excavatum, hypoplastic labia, scoliosis, 3-4 finger syndactyly, and 2-3 toe syndactyly. We present this case with a review of the literature for mixoploidy (the rare event of mosaicism for diploid and triploid cell lines). We add to the existing data on the clinical features of diploid/triploid mixoploidy. The complexities of the gastrointestinal problems make this case unusual.

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An epidemiologic study of irritable bowel syndrome in adolescents and children in South China: a school‐based study

Cited by 37 publications

References 9 publications

The Incidence of Irritable Bowel Syndrome in Children Using the Rome III Criteria and the Effect of Trimebutine Treatment

The Incidence of Irritable Bowel Syndrome in Children Using the Rome III Criteria and the Effect of Trimebutine Treatment

Mild Moxibustion Decreases the Expression of Prokineticin 2 and Prokineticin Receptor 2 in the Colon and Spinal Cord of Rats with Irritable Bowel Syndrome

Gastrointestinal Manifestations in Diploid/Triploid Mixoploidy

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