An Epidemic of Thrush in a Premature Nursery

Cremer, G; Groot, W.P. de

doi:10.1159/000254169

Cited by 17 publications

(3 citation statements)

References 4 publications

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“…Transmission between patients has also been related to inanimate surfaces as in an outbreak of thrush in a nursery for premature infants. The source of this outbreak was the nipple storage basin which was contaminated with Candida albicans (27). In addition, an epidemic of Candida parapsilosis peritonitis in a dialysis unit was related to environmental contamination; cultures of pigeon guano obtained from the window sills of this unit were found to be positive for Candida parapsilosis (28).…”

Section: Discussionmentioning

confidence: 99%

An experimental model for study ofCandida survival and transmission in human volunteers

Rangel‐Frausto

Houston

Bale

et al. 1994

Eur. J. Clin. Microbiol. Infect. Dis.

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In order to determine the potential for cross-transmission of Candida spp. between health-care workers and patients, the survival of clinical isolates of five species of Candida on the palms of human volunteers was tested. One hundred microliters of a McFarland 1.0 density suspension (5 x 10(5) cfu) from an overnight culture of Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis and Candida glabrata was used as inoculum. The degree of hydrophobicity of the different Candida species was also tested and did not influence the survival. The half-lives were brief, being 9.5, 12.4, 7.4, 12.8, 9.6 min for Candida albicans, Candida krusei, Candida glabrata, Candida parapsilosis, and Candida tropicalis, respectively, but at 45 min 2.6 x 10(3) to 3 x 10(4) organisms remained on the hands. Survival of Candida albicans for as long as 24 h on inanimate surfaces was observed. Transmission from one hand to a second hand occurred in 69% of the experiments and from the first to a third hand in 38%. Transmission to and from inanimate surfaces was successful in most of the experiments (90%). This experimental model aids in the biological study of Candida spp. and suggests some of the potential mechanisms of transmission.

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Section: Discussionmentioning

confidence: 99%

An experimental model for study ofCandida survival and transmission in human volunteers

Rangel‐Frausto

Houston

Bale

et al. 1994

Eur. J. Clin. Microbiol. Infect. Dis.

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“…Only two fomite isolates were found during the outbreak from 155 environmental samples and these were a dummy and a dropper, both of which were moist at the time of sampling. Other small episodes of cross-infection due to C. albicans have been reported by Cremer & de Groot (1967), Malamatinis, Mattmiller & Westfall (1968) and Marples et al (1985). Early awareness that cross-infection might be occurring was aided by the use of immunoblot fingerprinting which demonstrated that these patients were indeed being infected by the same strain of C. albicans.…”

Section: Discussionmentioning

confidence: 92%

Four outbreaks of nosocomial systemic candidiasis

et al. 1987

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Candida albicans has recently been described as a cause of nosocomial infection. This paper reports four further outbreaks occurring over a 12-month period in England. There were 13 systemic cases and 6 deaths. The outbreaks were defined by morphotyping and the new technique of immunoblot fingerprinting. Control of the outbreaks was produced by the implementation of strict cross-infection control policies without recourse to systemic chemoprophylaxis.

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“…Their doubts about the clinical significance and effective treatment of this parasite appears to be based on their experience with 32 patients, 27 of whom had pathogenic parasites, that was published 4 years ago (4). Sheehan (Markell and Udkow, Letter) has deaIt with this aspect succinctly, and Markell and Udkow's opinion is contrary to increasing evidence of the pathogenic potential of B. hominis (2,3,5,7,9).…”

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confidence: 99%