An epicardial delivery of nitroglycerine by active hydraulic ventricular support drug delivery system improves cardiac function in a rat model

Li, Xue; Mikrani, Reyaj; Li, Cunyu; Naveed, Muhammad; Liu, Ziwei; Abbas, Muhammad; Cheng, Yijie; Han, Lei; Wang, Zhijie; Zhou, Xiaohui

doi:10.1007/s13346-019-00656-9

Cited by 9 publications

(2 citation statements)

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“…Our previous study has confirmed the delivery of lidocaine by ASD was beneficial to reversing calcium chloride-induced ventricular fibrillation [19]. Similarly, ASD delivery of nitroglycerine has improved cardiac function and has a protective effect on the ischemic injury of the heart [39].…”

Section: Discussionmentioning

confidence: 76%

<strong></strong>Therapeutic Approach for Global Myocardial Injury Using Bone Marrow-Derived Mesenchymal Stem Cells by Cardiac Support Device in Rats

Liu¹,

Naveed²,

Mikrani³

et al. 2020

Preprint

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Bone marrow-derived mesenchymal stem cells (BMSCs) have been considered a promising therapeutic approach to cardiovascular disease. This study intends to compare the effect of BMSCs through a standard active cardiac support device (ASD) and intravenous injection on global myocardial injury induced by isoproterenol. BMSCs were cultured in vitro, and the transplanted cells were labeled with a fluorescent dye CM-Dil. Isoproterenol (ISO) was injected into the rats; two weeks later, the labeled cells were transplanted into ISO-induced heart-injury rats through the tail vein or ASD device for five days. The rats were sacrificed on the first day, the third day, and the fifth day after transplantation to observe the distribution of cells in the myocardium by fluorescence microscopy. The hemodynamic indexes of the left ventricle were measured before sacrificing. H&E staining and Masson’s trichrome staining were used to evaluate the cardiac histopathology. In the ASD groups, after three days of transplantation, there were many BMSCs on the epicardial surface, and after five days of transplantation, BMSCs were widely distributed in the ventricular muscle. But in the intravenous injection group, there were no labeled-BMSCs distributed. In the ASD+BMSCs-three days treated group and ASD+BMSCs -five days-treated group, left ventricular systolic pressure (LVSP), the maximum rate of left ventricular pressure rise (+dP/dt), the maximum rate of left ventricular pressure decline (-dP/dt) increased compared with model group and intravenous injection group (P<0.05). By giving BMSCs through ASD device, cells can rapidly and widely distribute in the myocardium and significantly improve heart function.

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Section: Discussionmentioning

confidence: 76%

<strong></strong>Therapeutic Approach for Global Myocardial Injury Using Bone Marrow-Derived Mesenchymal Stem Cells by Cardiac Support Device in Rats

Liu¹,

Naveed²,

Mikrani³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…An implantable catheter was first connected to the device and then tunnelled subcutaneously through the second intercostal space to the anterior chest wall, exiting the thoracic cavity via a 1 cm opening on the skin for drug administration. [26,27] 1.1.2 Catheter system-based delivery approaches for drug instillation and infusion via medial sternotomy Vereckei et al described a method to infuse anti-fibrillatory drug, ibutilide, into the pericardial space of dogs using a 4.1 Fr fenestrated catheter. [6] The catheter was positioned in the pericardial space via a small incision on the pericardium created after medial sternotomy.…”

Section: Opened Pericardium-based Delivery Approaches For Drug Instil...mentioning

confidence: 99%

Access routes, devices and guidance methods for intrapericardial delivery in cardiac conditions

Ho¹,

Craig²,

Day³

2022

Trends in Cardiovascular Medicine

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Patient Medicine Reminder System

Harish¹

2021

Springer Proceedings in Materials

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An epicardial delivery of nitroglycerine by active hydraulic ventricular support drug delivery system improves cardiac function in a rat model

Cited by 9 publications

References 47 publications

<strong></strong>Therapeutic Approach for Global Myocardial Injury Using Bone Marrow-Derived Mesenchymal Stem Cells by Cardiac Support Device in Rats

<strong></strong>Therapeutic Approach for Global Myocardial Injury Using Bone Marrow-Derived Mesenchymal Stem Cells by Cardiac Support Device in Rats

Access routes, devices and guidance methods for intrapericardial delivery in cardiac conditions

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