An epicardial bioelectronic patch made from soft rubbery materials and capable of spatiotemporal mapping of electrophysiological activity

Sim, Kyoseung; Ershad, Faheem; Zhang, Yongcao; Yang, Peixu; Shim, Hyunseok; Rao, Zhoulyu; Lu, Yuntao; Thukral, Anish; Elgalad, Abdelmotagaly; Xi, Yutao; Tian, Bozhi; Taylor, Doris A.; Yu, Cunjiang

doi:10.1038/s41928-020-00493-6

Cited by 157 publications

(138 citation statements)

References 57 publications

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“…Naturally, the durability of the leads is of critical importance. Current research seeks to design soft devices with properties similar to the surrounding tissues to optimize seamless integration and minimize damage ( Sim et al 2020 ). Mechanical damage can result in pacing lead failure and the loss of electrical function ( Mulpuru et al 2017 ).…”

Section: Cardiac Mechanics—pacing Lead Failurementioning

confidence: 99%

Precision medicine in human heart modeling

Peirlinck

Costabal

Jiang

et al. 2021

Biomech Model Mechanobiol

115

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Precision medicine is a new frontier in healthcare that uses scientific methods to customize medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person. In cardiovascular health, precision medicine has emerged as a promising paradigm to enable cost-effective solutions that improve quality of life and reduce mortality rates. However, the exact role in precision medicine for human heart modeling has not yet been fully explored. Here, we discuss the challenges and opportunities for personalized human heart simulations, from diagnosis to device design, treatment planning, and prognosis. With a view toward personalization, we map out the history of anatomic, physical, and constitutive human heart models throughout the past three decades. We illustrate recent human heart modeling in electrophysiology, cardiac mechanics, and fluid dynamics and highlight clinically relevant applications of these models for drug development, pacing lead failure, heart failure, ventricular assist devices, edge-to-edge repair, and annuloplasty. With a view toward translational medicine, we provide a clinical perspective on virtual imaging trials and a regulatory perspective on medical device innovation. We show that precision medicine in human heart modeling does not necessarily require a fully personalized, high-resolution whole heart model with an entire personalized medical history. Instead, we advocate for creating personalized models out of population-based libraries with geometric, biological, physical, and clinical information by morphing between clinical data and medical histories from cohorts of patients using machine learning. We anticipate that this perspective will shape the path toward introducing human heart simulations into precision medicine with the ultimate goals to facilitate clinical decision making, guide treatment planning, and accelerate device design.

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Section: Cardiac Mechanics—pacing Lead Failurementioning

confidence: 99%

Precision medicine in human heart modeling

Peirlinck

Costabal

Jiang

et al. 2021

Biomech Model Mechanobiol

115

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“…Implantable bioelectronics, offering many benefits (such as real‐time continuous health monitoring and precision therapies), have become commonplace. [ 1–13 ] Over the past few decades, enormous advancements have been made in implantable bioelectronics. Figure illustrates a historical overview of implantable bioelectronics.…”

Section: Introductionmentioning

confidence: 99%

“…[ 14 ] Since then, various state‐of‐the‐art implantable electronics designed for specific biomedical applications have been proposed and expected to treat millions of patients. [ 2,8,15–22 ] A future trend in implantable bioelectronics will shift toward soft, miniaturized, wireless, biodegradable, micro/nano‐systems with multi‐functions. Such bioelectronics typically consists of programmable circuits, communication modules, [ 23–26 ] biosensing systems, [ 27–30 ] and actuators [ 31–35 ] that require energy to accomplish the tasks for which they are designed.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances of Energy Solutions for Implantable Bioelectronics

Sheng

Zhang

Liang

et al. 2021

Adv Healthcare Materials

Self Cite

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The emerging field of implantable bioelectronics has attracted widespread attention in modern society because it can improve treatment outcomes, reduce healthcare costs, and lead to an improvement in the quality of life. However, their continuous operation is often limited by conventional bulky and rigid batteries with a limited lifespan, which must be surgically removed after completing their missions and/or replaced after being exhausted. Herein, this paper gives a comprehensive review of recent advances in nonconventional energy solutions for implantable bioelectronics, emphasizing the miniaturized, flexible, biocompatible, and biodegradable power devices. According to their source of energy, the promising alternative energy solutions are sorted into three main categories, including energy storage devices (batteries and supercapacitors), internal energy‐harvesting devices (including biofuel cells, piezoelectric/triboelectric energy harvesters, thermoelectric and biopotential power generators), and external wireless power transmission technologies (including inductive coupling/radiofrequency, ultrasound‐induced, and photovoltaic devices). Their fundamentals, materials strategies, structural design, output performances, animal experiments, and typical biomedical applications are also discussed. It is expected to offer complementary power sources to extend the battery lifetime of bioelectronics while acting as an independent power supply. Thereafter, the existing challenges and perspectives associated with these powering devices are also outlined, with a focus on implantable bioelectronics.

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“…Epidemical wearable sensors offer a more promising approach due to their light weight, low cost, flexibility, and stretchability [ 18 , 19 ]. We can obtain personal physical information by monitoring the heartbeat [ 20 , 21 ], pulse [ 22 , 23 ], sweat [ 24 , 25 ], and even respiration [ 21 , 26 , 27 ] with the help of these sensors. But extracting physiological information from tendon activities is still rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Active-Sensing Epidermal Stretchable Bioelectronic Patch for Noninvasive, Conformal, and Wireless Tendon Monitoring

Shu

Chen

et al. 2021

Research

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Sensors capable of monitoring dynamic mechanics of tendons throughout a body in real time could bring systematic information about a human body’s physical condition, which is beneficial for avoiding muscle injury, checking hereditary muscle atrophy, and so on. However, the development of such sensors has been hindered by the requirement of superior portability, high resolution, and superb conformability. Here, we present a wearable and stretchable bioelectronic patch for detecting tendon activities. It is made up of a piezoelectric material, systematically optimized from architectures and mechanics, and exhibits a high resolution of 5.8×10−5 N with a linearity parameter of R2=0.999. Additionally, a tendon real-time monitoring and healthcare system is established by integrating the patch with a micro controller unit (MCU), which is able to process collected data and deliver feedback for exercise evaluation. Specifically, through the patch on the ankle, we measured the maximum force on the Achilles tendon during jumping which is about 16312 N, which is much higher than that during normal walking (3208 N) and running (5909 N). This work not only provides a strategy for facile monitoring of the variation of the tendon throughout the body but also throws light on the profound comprehension of human activities.

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An epicardial bioelectronic patch made from soft rubbery materials and capable of spatiotemporal mapping of electrophysiological activity

Cited by 157 publications

References 57 publications

Precision medicine in human heart modeling

Precision medicine in human heart modeling

Recent Advances of Energy Solutions for Implantable Bioelectronics

Active-Sensing Epidermal Stretchable Bioelectronic Patch for Noninvasive, Conformal, and Wireless Tendon Monitoring

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