An enzyme-controlled Janus nanomachine for on-command dual and sequential release

Pérez-Calabuig, Ana M.; Díez, Paula; Martı́nez-Ruiz, Paloma; Martínez‐Máñez, Ramón; Sánchez, Alfredo; Villalonga, Reynaldo

doi:10.1039/d0cc01234c

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…Completely opposite trend is followed in case of faster-growing tumors. Villalonga et al designed a novel nanomachine for sequential release of two different compounds 45 . The nanoparticles were grafted with sulfhydryl groups and pH-sensitive β-CD gated integration on the surface of gold mesoporous silica modified by acetylcholinesterase.…”

Section: Co-transport Of Different Drug Combinationsmentioning

confidence: 99%

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Yi¹,

Liao²,

Zhao³

et al. 2022

Theranostics

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In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the required standard of effectiveness, primarily owing to issues of drug resistance exhibited by cancer cells and inherent differences among the patients. In this regard, combination therapy offers advantages of synergistic mechanism, reduced drug dosage, and enhanced therapeutic effect, which can be effectively utilized for the treatment of cancer. However, different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo , which lead to uncontrollable concentration ratio of therapeutic agents at the lesion site. This in turn causes serious side effects and affects synergistic anticancer effect. Importantly, multifunctional co-delivery systems are characterized by good pharmacokinetic properties, ability to provide targeted delivery, and controlled release in response to tumor microenvironment. Such delivery systems are widely used for co-delivery of therapeutic agents, which further assist in obtaining better synergistic anticancer effect, and can be potentially used for clinical application. Multifunctional co-delivery systems often exhibit complex structures and construction process. Since cyclodextrin is characterized by self-assembly property, it is possible to quickly construct cyclodextrin-based multifunctional co-delivery systems, with convenience and flexibility. The application of cyclodextrin in the construction of multifunctional co-delivery systems for cancer therapy has gained immense attention in the past few years. The present study provided overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy.

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Section: Co-transport Of Different Drug Combinationsmentioning

confidence: 99%

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Yi¹,

Liao²,

Zhao³

et al. 2022

Theranostics

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“…Marcelo and colleagues reported on the production of Janus nanoparticles consist of gold and MSNs. The term Janus nanoparticles refer to the side-by-side position of gold and MSNs [ 93 ]. Another common inorganic-MSNs hybrid is iron oxide and MSNs hybrid.…”

Section: Fabrication Of Msnsmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

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“…16,17 These colloids have been employed to construct integrated enzyme-controlled nanomachines for the selective and autonomous delivery of drugs and other compounds, triggered by single and multiple chemical input signals. 18–20 Au–MSN Janus nanomachines with enzymatic control have also been employed to create novel particle-to-particle and particle-to-cell communication protocols based on the autonomous exchange of chemical messengers. 21,22…”

Section: Introductionmentioning

confidence: 99%

An intercommunicated nanosystem for dual delivery

Mayol,

Rodríguez,

Villalonga

et al. 2023

J. Mater. Chem. B

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An enzyme-controlled Janus nanomachine for on-command dual and sequential release

Abstract: A novel multi-stimuli responsive Janus nanomachine with enzymatic control for dual and sequential release of two different payloads was developed.

Cited by 9 publications

References 22 publications

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

An intercommunicated nanosystem for dual delivery

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