An enzymatic cow immunity-targeted approach to reducing milk somatic cell count. 1. A preliminary study using lysosubtilin

An enzymatic cow immunity-targeted approach to reducing milk somatic cell count: 3. A comparative field trial

“…An average 40.6% and 58.5% reduction of SCC was observed on the tenth day of the trial in milk of cows that were given lysosubtilin and lysozyme (individually), respectively. The results achieved are in a rather close correlation with the previous ones (Biziulevičius et al 2003a, Sederevičius et al 2005). It appears that lytic carbohydrases (represented in this study by lysozyme) have greater potential for future studies than lytic endopeptidases (represented in this study by lysosubtilin).…”

“…In this regard, dietary supplementation with vitamins (in amounts usually greater than are required for nutritional adequacy) has already revealed itself as a prospective tool for reduction of milk SCC , Politis et al 1995, Hemingway 1999. The same holds true for enzymes; it has been shown recently that milk SCC can be significantly reduced by the use of antimicrobial enzyme preparations lysosubtilin and lysozyme (Biziulevičius et al 2003a, Sederevičius et al 2005.…”

“…An average 43.9% and 50.4% reduction of milk SCC (with no negative impact on haematological and milk indices) was achieved when using lysosubtilin (Biziulevičius et al 2003a) and bacterial lysozyme (Sederevičius et al 2005) for ten successive days at daily doses of 0.02 and 0.2 g kg wt (1 , respectively. It must be said for the sake of truth that these effects were achieved at quite different conditions (the study with lysosubtilin was performed in early spring, whilst the study with lysozyme was performed in autumn) and thus the results are hard to compare.…”

“…Our recent studies (Biziulevičius et al 2003a, Sederevičius et al 2005) have revealed that an enzymatic cow immunity-targeted approach to reducing milk SCC gives a real result. An average 43.9% and 50.4% reduction of milk SCC (with no negative impact on haematological and milk indices) was achieved when using lysosubtilin (Biziulevičius et al 2003a) and bacterial lysozyme (Sederevičius et al 2005) for ten successive days at daily doses of 0.02 and 0.2 g kg wt (1 , respectively.…”

An enzymatic cow immunity-targeted approach to reducing milk somatic cell count: 2. A study using lysozyme

“…The attempts to employ extracellular lytic enzymes as immunostimulants for reducing the milk somatic cell count (SCC) in cows performed by oral application of lysosubtilin as a model enzyme preparation were positive (Biziulevičius et al 2003a). In this communication updated findings with regard to the evaluation of an enzymatic approach to reducing milk SCC achieved by using a bacterial lysozyme preparation are described.…”