Where do the immunostimulatory effects of oral proteolytic enzymes (‘systemic enzyme therapy’) come from? Microbial proteolysis as a possible starting point

Biziulevičius, Gediminas A.

doi:10.1016/j.mehy.2006.05.051

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…In the human body, various enzymes are essential for processes involving protein hydrolysis in cells and tissues—including angiogenesis, along with tissue morphogenesis and repair—through which pain, swelling of tissues, and healing time are reduced. 96 Thus, enzyme therapy is sometimes used, with oral administration being the most common route for systemic diseases. Ingested enzymes have been shown to protect against oxidative stress and affect cell signalling and immune function.…”

Section: Therapeutic Use Of Trypsinmentioning

confidence: 99%

Tryptase and Exogenous Trypsin: Mechanisms and Ophthalmic Applications

Li¹,

Lu²,

Li³

et al. 2023

JIR

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Ocular injuries caused by inflammation, surgery or accidents are subject to a physiological healing process that ultimately restores the structure and function of the damaged tissue. Tryptase and trypsin are essential component of this process and they play a role in promoting and reducing the inflammatory response of tissues, respectively. Following injury, tryptase is endogenously produced by mast cells and can exacerbate the inflammatory response both by stimulating neutrophil secretion, and through its agonist action on proteinase-activated receptor 2 (PAR2). In contrast, exogenously introduced trypsin promotes wound healing by attenuating inflammatory responses, reducing oedema and protecting against infection. Thus, trypsin may help resolve ocular inflammatory symptoms and promote faster recovery from acute tissue injury associated with ophthalmic diseases. This article describes the roles of tryptase and exogenous trypsin in affected tissues after onset of ocular injury, and the clinical applications of trypsin injection.

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Section: Therapeutic Use Of Trypsinmentioning

confidence: 99%

Tryptase and Exogenous Trypsin: Mechanisms and Ophthalmic Applications

Li¹,

Lu²,

Li³

et al. 2023

JIR

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show abstract

“…Microbial proteases are increasingly used in treatment of various disorders such as cancer, inflammation, cardiovascular disorders, necrotic wounds, etc (Chanalia et al,2011). Proteases are also used an immunostimulants (Biziulenvicius, 2006). Proteases are used extensively in the pharmaceutical industry for preparation of medicines such as ointments for debridement of wounds.…”

Section: Medicinal Industrymentioning

confidence: 99%

Protease Production from Polyextremophilic Bacteria

Sharma¹,

Mathur²,

Singh³

2016

Int.J.Curr.Res.Aca.Rev.

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“…This type of enzyme is of special importance in view of the clinical use of BCWH (see below). Proteases capable to lyse bacteria were not given a place in the authors’ classification as well; in this latter regard, it seems that the authors did not think about the question of where does the borderline between ‘proteases’, ‘lytic proteases’ and ‘lytic enzymes’ lie (Biziulevičius 2006) at all.…”

mentioning

confidence: 99%