An Enlarging Hepatic Mass of Unknown Etiology

Skaret, Michael M.; Vicente, Diego; Deising, Adam

doi:10.1053/j.gastro.2020.06.054

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…( 17 ) in 1976, is now also classified as PEComa. Recent papers reported a prevalence of hepatic PEComa to be 300-600 cases, but it is problematic to estimate true epidemiology ( 18 , 19 ). There is a higher prevalence of various neoplasms in organ transplant recipients ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

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Case report: Liver PEComa after kidney transplantation in recipient with tuberous sclerosis complex

Dymkowski,

Kalman,

Niecikowski

et al. 2024

Front. Oncol.

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IntroductionPerivascular epithelioid cell tumors (PEComa) are rare tumors of mesenchymal origin that exhibit perivascular epithelioid cell phenotype. One of its most common localizations is uterus, whereas only a few studies reported PEComa localization as liver. There is a correlation between the presence of PEComa and tuberous sclerosis complex (TSC). TSC is a rare disease which leads to the development of mostly non-cancerous tumors in various organs. We would like to present a case of a kidney transplant recipient with a PEComa detected post-transplant in the liver.Case reportA 27-year-old patient, 3 years after kidney transplantation (KTx) due to chronic renal failure in the course of autosomal dominant polycystic kidney disease and concomitant TSC, was admitted to the Clinic and Department of General and Transplant Surgery for abnormal findings in computed tomography (CT). A CT scan was conducted for oncological follow-up after a kidney transplant (KTx) because before the transplantation, a small cystic lesion measuring 7 mm in diameter was removed from the donor kidney and diagnosed as papillary renal cell carcinoma (PRCC). Two tumors in the liver were detected - one 27mm in diameter in segment VII/VIII and the other 8mm in diameter in segment II/III. Because of typical radiological signs hepatocellular carcinoma was suspected, but the serum level of alpha fetoprotein was within normal limits and liver function was preserved. The intraoperative biopsy and the radiofrequency ablation (RFA) of the larger tumor were performed three months later. In the histopathological examination benign PEComa (HMB45 +, Melan A +) was detected.ConclusionThe oncological surveillance made it possible to detect liver lesion in early stage and in 3,5-year follow-up no sign of recurrence of PEComa was found. This case is the second to show RFA as treatment method of liver PEComa and first in kidney transplant recipient.

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Section: Discussionmentioning

confidence: 99%

“…In liver PEComa, those criteria were not validated. Case reports of hepatic lesions with malignant behavior were reported and most of them did not meet the criteria ( 18 , 28 , 41 – 44 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Liver PEComa after kidney transplantation in recipient with tuberous sclerosis complex

Dymkowski,

Kalman,

Niecikowski

et al. 2024

Front. Oncol.

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“…1,2 Their most frequent location is the uterus, followed by the kidneys, bladder, prostate, lung, pancreas, and liver. 2 Primary hepatic PEComa is extremely rare, with most cases being benign, and only a few cases being malignant. Based on some case reports published, the abnormal FDG distribution in PEComa varies widely.…”

Section: Figurementioning

confidence: 99%

“…In a follow-up period of 6 months after transcatheter arterial chemoembolization, the tumor had shrunk without metastasis by MRI. PEComas are a rare group of mesenchymal tumors, distinguished by epithelioid cells with perivascular disposition, which express myogenic and melanocytic markers 1,2. Their most frequent location is the uterus, followed by the kidneys, bladder, prostate, lung, pancreas, and liver 2.…”

mentioning

confidence: 99%

“…PEComas are a rare group of mesenchymal tumors, distinguished by epithelioid cells with perivascular disposition, which express myogenic and melanocytic markers 1,2. Their most frequent location is the uterus, followed by the kidneys, bladder, prostate, lung, pancreas, and liver 2. Primary hepatic PEComa is extremely rare, with most cases being benign, and only a few cases being malignant.…”

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confidence: 99%

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Comparison of 18F-FDG and 68Ga-FAPI PET/CT in a Patient With Hepatic Perivascular Epithelioid Cell Neoplasm

Li,

Su,

Zhou

et al. 2023

Clin Nucl Med

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The prevalence of hepatic perivascular epithelioid cell neoplasm (PEComa) is extremely low, and imaging diagnosis is very difficult. We presented 18F-FDG and 68Ga-FAPI PET/CT findings in a 58-year-old woman with pathologically confirmed hepatic PEComa. The tumor showed intense 68Ga-FAPI uptake but only mild 18F-FDG activity on PET/CT studies. This case suggested that 68Ga-FAPI PET/CT might be a useful tool for evaluation of hepatic PEComa with remarkable tumor-to-liver ratios.

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Hepatic epithelioid angiomyolipoma: magnetic resonance imaging characteristics

Zhang²,

Guo³

et al. 2023

Abdom Radiol

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An Enlarging Hepatic Mass of Unknown Etiology

Cited by 4 publications

References 2 publications

Case report: Liver PEComa after kidney transplantation in recipient with tuberous sclerosis complex

Case report: Liver PEComa after kidney transplantation in recipient with tuberous sclerosis complex

Comparison of 18F-FDG and 68Ga-FAPI PET/CT in a Patient With Hepatic Perivascular Epithelioid Cell Neoplasm

Hepatic epithelioid angiomyolipoma: magnetic resonance imaging characteristics

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