Comparison of 18F-FDG and 68Ga-FAPI PET/CT in a Patient With Hepatic Perivascular Epithelioid Cell Neoplasm

Abstract

The prevalence of hepatic perivascular epithelioid cell neoplasm (PEComa) is extremely low, and imaging diagnosis is very difficult. We presented 18F-FDG and 68Ga-FAPI PET/CT findings in a 58-year-old woman with pathologically confirmed hepatic PEComa. The tumor showed intense 68Ga-FAPI uptake but only mild 18F-FDG activity on PET/CT studies. This case suggested that 68Ga-FAPI PET/CT might be a useful tool for evaluation of hepatic PEComa with remarkable tumor-to-liver ratios.

Intense 18F-FAPI Uptake in Small Recurrent Lesions of Combined Hepatocellular-Cholangiocarcinoma Negative on 18F-FDG PET/CT

“…Several studies have demonstrated that 68 Ga/ 18 F-FAPI PET/CT is more effective than 18 F-FDG PET/CT in detecting primary and recurrent liver cancers, including hepatocellular carcinoma, 4-6 intrahepatic cholangiocarcinoma, 5,6 mucosa-associated lymphoid tissue, 7 liver metastases, 8,9 and some benign liver diseases. 6,[10][11][12] In our case, significant 18 F-FAPI uptake was observed, suggesting that 18…”

Hepatic perivascular epithelioid cell tumors: The importance of preoperative diagnosis

“…The authors reported that PEComas exhibited strong 68Ga-FAPI uptake and slight 18F-FDG activity. This means that 68Ga-FAPI PET/CT has the potential to become a diagnostic tool for PEComas[ 21 ].…”

18F-FAPI for Imaging Metastatic Perivascular Epithelioid Cell Neoplasm

“…This rare case report highlights the utility of 18 F-FAPI PET in the evaluation of PEComas and suggests that 18 F-FAPI PET/CT might play a more beneficial role than 18 F-FDG PET/CT in identifying and assessing the extent of PEComas. 10…”