An enhanced benchmark for prosthetic joint replacement infection rates

Barnes, Sue; Salemi, Charles; Fithian, Donald C.; Akiyama, Lois; Barron, Dana; Eck, Enid K.; Hoare, Kathy

doi:10.1016/j.ajic.2006.04.207

Cited by 32 publications

(18 citation statements)

References 18 publications

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“…One of the reasons is that prostheses are positioned under special circumstances beyond immune control, and the infection rate for joint replacements alone approaches 3.0%. 1,2 Consequently, the alternative technique of adding antibacterial agents or materials to the surface of the implant itself, as in the case of cementless implants, has been developed. [3][4][5][6][7][8][9] In previous study, along these lines, we have described the development of a thermal sprayed silver-containing hydroxyapatite (HA) coating, 10 which combined silver (Ag) presenting with a wide spectrum of antibacterial activity, low incidence of resistance, and the ability to inhibit bacterial colonization, 9,11 with HA displaying good biocompatibility and osteoconductivity.…”

Section: Introductionmentioning

confidence: 99%

In vivo antibacterial and silver‐releasing properties of novel thermal sprayed silver‐containing hydroxyapatite coating

Shimazaki¹,

Miyamoto²,

Ando³

et al. 2009

J Biomed Mater Res

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One of the serious postoperative complications associated with joint replacement is bacterial infection. In addressing this problem, we have previously described the development of a novel thermal spraying technology combining silver (Ag) showing antibacterial activity with hydroxyapatite (HA) displaying good biocompatibility and osteoconductivity, and reported the in vitro properties. This study evaluated serum Ag ion concentrations and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) using a subcutaneous rat model. HA loaded with 3 wt % of silver oxide (Ag-HA) and plain HA were sprayed on the surface of titanium disks. Ag-HA- or HA-coated samples were implanted into the back subcutaneous pockets of male Sprague-Dawley rats. Mean serum Ag ion concentration in the Ag-HA group increased to more than 50 ppb by 48 h after implantation, then decreased gradually to baseline levels. Mean (+/- standard error of the mean) number of viable MRSA on HA coating was (1.5 +/- 0.5) x 10(5), which is significantly more than the (1.1 +/- 0.4) x 10(4) on Ag-HA coating (p < 0.001). Ag-HA coating offers good abilities to release Ag ions and kill MRSA in vivo.

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Section: Introductionmentioning

confidence: 99%

In vivo antibacterial and silver‐releasing properties of novel thermal sprayed silver‐containing hydroxyapatite coating

Shimazaki¹,

Miyamoto²,

Ando³

et al. 2009

J Biomed Mater Res

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“…The use of prosthetic joints has increased gradually for the purpose of improving the mobility of individuals with degenerative joints (2,3). Infections may complicate 1%-5% of prosthetic joints and Staphylococcus is the most common agent of prosthetic joint infection (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Infections may complicate 1%-5% of prosthetic joints and Staphylococcus is the most common agent of prosthetic joint infection (3,4). NTM is an infrequent cause of prosthetic joint infections.…”

Section: Introductionmentioning

confidence: 99%

Septic Arthritis Caused by Mycobacterium fortuitum and Mycobacterium abscessus in a Prosthetic Knee Joint: Case Report and Review of Literature

et al. 2011

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Nontuberculous mycobacterium (NTM) is an infrequent cause of prosthetic knee joint infections. Simultaneous infection with different NTM species in a prosthetic knee joint has not been previously reported. A case of prosthetic knee joint infection caused by Mycobacterium abscessus and M. fortuitum is described in this report. The patient was successfully treated with adequate antibiotics and surgery. The clinical features of sixteen previously reported cases of prosthetic knee joint infection caused by NTM are reviewed.

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“…One major limitation to this study is the use of ICD‐9 codes to identify patients diagnosed with SSI. Physicians use variable codes to record SSI and surveillance for SSI is often inadequate . Patients may develop SSI after discharge.…”

Section: Discussionmentioning

confidence: 99%

Empiric evidence for a genetic contribution to predisposition to surgical site infection

Lee

Hopf

Cannon‐Albright

2013

Wound Repair Regeneration

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The genetics of microbial pathogens have been extensively studied, but there has been little work on human genetic susceptibility to surgical site infection (SSI). We analyzed a large genealogical population database to study the familial contribution to SSI. We analyzed 651 individuals with ICD-9 codes indicating presence of SSI. Matched hospital controls were randomly selected from the database based on birth year, sex and birthplace. The average relatedness of all possible pairs of cases, and separately of controls (x1000 sets) was compared empirically. The relative risk for SSI was estimated by comparing the number of observed affected individuals among the relatives of cases to the number of affected individuals observed among relatives of matched hospital controls. The Genealogical Index of Familiality test for patients with SSI showed significant excess relatedness (p< 0.010); this excess was still observed when close relationships were ignored (p=0.019). The RR for third-degree relatives of cases was significantly elevated (1.62, p = 0.029). The significant excess relatedness and the significantly elevated RR to distant relatives support a genetic predisposition to acquiring SSI.

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An enhanced benchmark for prosthetic joint replacement infection rates

Cited by 32 publications

References 18 publications

In vivo antibacterial and silver‐releasing properties of novel thermal sprayed silver‐containing hydroxyapatite coating

In vivo antibacterial and silver‐releasing properties of novel thermal sprayed silver‐containing hydroxyapatite coating

Septic Arthritis Caused by Mycobacterium fortuitum and Mycobacterium abscessus in a Prosthetic Knee Joint: Case Report and Review of Literature

Empiric evidence for a genetic contribution to predisposition to surgical site infection

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