<i>In vivo</i> antibacterial and silver‐releasing properties of novel thermal sprayed silver‐containing hydroxyapatite coating

Shimazaki, Takafumi; Miyamoto, Hiroshi; Ando, Yumiko; Noda, Ichiro; Yonekura, Yutaka; Kawano, Seiji; Miyazaki, Masaki; Mawatari, Masaaki; Hotokebuchi, Takao

doi:10.1002/jbm.b.31526

Cited by 85 publications

(72 citation statements)

References 26 publications

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“…50 Thus far, only a few in-vivo antibacterial studies of AgHA-IE coated implants were examined. 53,54,59 Kose et al 59 produced AgHA-IE nanocoatings via electrospray technique with a silver content of 5.5 wt.%. S. aureus and methicillin-resistant S. aureus (MRSA) were used to create infections on the left knee of 27 rabbits.…”

Section: Deposition Of Agha Nanocoatingsmentioning

confidence: 99%

Development of nanosized silver-substituted apatite for biomedical applications: A review

Lim

Lei

Thian

2015

Nanomedicine: Nanotechnology, Biology and Medicine

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Section: Deposition Of Agha Nanocoatingsmentioning

confidence: 99%

Development of nanosized silver-substituted apatite for biomedical applications: A review

Lim

Lei

Thian

2015

Nanomedicine: Nanotechnology, Biology and Medicine

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“…To our current knowledge, the only published structure is the one published by Acland and Freeman 31 for Gly−Gly, the simplest of all dipeptides. At pH = 6, this dipeptide forms a dimeric complex 8 in which two silver (8) ions connect the C-termini of the dipeptides via Ag−O bonds, forming an eight-membered ring ( Figure 3). Even for peptides frequently used in combination with silver such as glutathione (GSH) (see section 2.2) or the AG4-peptide (see section 2.3.1), no crystal structure has been published.…”

Section: Silver Binding To Amino Acids and Peptidesmentioning

confidence: 99%

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

et al. 2013

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Introduction 4708 2. Peptides and Silver 4709 2.1. Silver Binding to Amino Acids and Peptides 4709 2.1.1. Silver Binding to Amino Acids − Theory 4709 2.1.2. Silver Binding to Amino Acids − Experiment 4711 2.1.3. Silver Binding to Peptides 4711 2.2. Natural Peptides Involved in Metal Detoxification 4714 2.3. Peptides for the Formation of Silver Nanostructures 4716 2.3.1. Biomineralization of Silver by Means of Peptides 4716 2.3.2. Peptides as Structure-Determining Scaffolds in the Synthesis of Silver Nanostructures 4721 3. Bacteria and Silver 4722 3.1. Antimicrobial Properties of Silver-Containing Compounds 4722 3.1.1. Interactions with the Bacterial Cell Wall 4722 3.1.2. Interactions with DNA, Enzymes, and Membrane Proteins 4724 3.1.3. Generation of Reactive Oxygen Species 4725 3.2. Bacterial Resistance Mechanisms against Ag(I) 4726 3.2.1. Accumulation and Storage-Based Mechanism 4726 3.2.2. Efflux Pump-Based Mechanism 4727 3.3. Synthesis of Silver Nanoparticles by Means of Bacteria 4728 4. Silver-Based Biomaterials in the Medical Field 4730 4.1. Types of Silver-Containing Biomaterials 4731 4.1.1. Metallic Silver Coatings and Silver's Antimicrobial Efficiency 4731 4.1.2. Silver-Containing Nanocomposites 4732 4.1.3. Silver-Containing Polymers 4732 4.1.4. Surface Modification with Ionic Silver Compounds 4734 4.1.5. Hybrid Silver Materials − Synergistic Effects 4734 4.2. Deposition Processes 4735 4.3. Mechanical Properties 4736 5. Biocompatibility of Silver 4737 5.1. General Routes of Silver Exposure 4737 5.2. Exposure to Silver-Containing Medical Products 4737 5.2.1. Dermal Contact: Burn Wound Dressings 4737 5.2.2. Bone Contact: Orthopedic and Dental Implants and Bone-Filling Products 4738 5.2.3. Blood Contact: Implants Introduced into the Vascular System 4739 5.3. Effects of Silver Exposure on Tissues and Organs 4739 5.3.1. Acute and Chronic Toxicity of Silver 4740 5.3.2. Tissue and Organ Damages 4740 5.3.3. Cellular Uptake of Silver 4741 5.4. Toxic Effects of Silver Nanoparticles 4741 5.5. Silver Detoxification 4742 5.5.1. Sequestration of Silver Ions 4742 5.5.2. Silver Ion Transport by ATPase P-type Efflux Pumps 4743 6. Conflicting Evidence 4744 7. Conclusions 4744 Author Information 4744 Corresponding Author 4744 Notes 4744 Biographies 4745 Acknowledgments 4746 References 4746

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“…Thus, co-deposition gives good long-term antimicrobial cover but with loss of the 'peak effect', as there is limited bactericidal effect in the initial period. 52 Shimazaki et al 53 conducted a study in which AgHA-coated titanium plates were implanted subcutaneously in the backs of Sprague-Dawley rats, comparing Ag-HAcoated plates with HAcoated plates in terms of their activity against MRSA. The results demonstrated significantly fewer MRSA CFUs on the Ag-HA-coated plates, showing promise for the use of such coatings clinically.…”

Section: Hydroxyapatite (Ha) Coatingmentioning

confidence: 99%

Silver nanoparticles and their orthopaedic applications

Brennan

Fhoghlu

Devitt

et al. 2015

The Bone & Joint Journal

150

114

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Implant-associated infection is a major source of morbidity in orthopaedic surgery. There has been extensive research into the development of materials that prevent biofilm formation, and hence, reduce the risk of infection. Silver nanoparticle technology is receiving much interest in the field of orthopaedics for its antimicrobial properties, and the results of studies to date are encouraging. Antimicrobial effects have been seen when silver nanoparticles are used in trauma implants, tumour prostheses, bone cement, and also when combined with hydroxyapatite coatings. Although there are promising results with in vitro and in vivo studies, the number of clinical studies remains small. Future studies will be required to explore further the possible side effects associated with silver nanoparticles, to ensure their use in an effective and biocompatible manner. Here we present a review of the current literature relating to the production of nanosilver for medical use, and its orthopaedic applications. Silver is a soft, white, lustrous transition metal which is recognised to have antimicrobial properties and has assumed an important role in the treatment of infections.1-3 As a non-specific biocidal agent, in suitable doses silver is not toxic to mammalian cells and disinfects a broad spectrum of bacterial and fungal species, including antibiotic-resistant strains.1-3 Silver and silver nanoparticles are used as antimicrobials in a variety of industrial, healthcare and domestic applications. 4,5 Silver has been incorporated into wound dressings, and as an antimicrobial coating on medical devices in order to prevent biofilm formation.6 The clinical potential of silver nanotechnology is of particular interest to the field of orthopaedics, where infection of implanted devices represents a persistent threat. In this paper we provide a review of the literature on the use of silver nanoparticles and their application in the field of orthopaedics. In addition, we review the potential for toxicity if silver is not used with caution.

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In vivo antibacterial and silver‐releasing properties of novel thermal sprayed silver‐containing hydroxyapatite coating

Cited by 85 publications

References 26 publications

Development of nanosized silver-substituted apatite for biomedical applications: A review

Development of nanosized silver-substituted apatite for biomedical applications: A review

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

Silver nanoparticles and their orthopaedic applications

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