Measurements
of clouding phenomena in Triton X-100 (TX-100) were
carried out in the aqueous system and the presence of the antibiotic
drug levofloxacin hemihydrate (LFH)/(LFH + inorganic salts/alcohols)
and were explained thoroughly. In the aqueous system, the observed
values of cloud point (CP) of TX-100 increased continuously with the
increasing concentration of TX-100. In the occurrence of LFH, the
magnitudes of cloud point of a certain concentration of TX-100 were
found to increase first, and after that, the CP value declined with
increasing concentration of the drug. The magnitudes of CP for the
LFH + TX-100 mixed system were found to be dwindled through the enrichment
of salt concentration in the presence/absence of a drug (LFH). The
CP values in the presence of salts follow the order K2SO4 < KNO3 < K3PO4. On
the other hand, in the case of alcohol solvent, the CP values decreased
from lower alcohol to higher alcohol and increased through the enrichment
of alcohol concentration in the presence and absence of a drug (LFH).
Various types of thermodynamics parameters, such as standard free
energy (ΔG
0
c), standard
enthalpy (ΔH
0
c), and
standard entropy (ΔS
0
c) changes of phase separation, were also determined and explained
in an extent on the basis of their nature. The values of free energy
changes (ΔG
0
c) were positive,
which indicated that the clouding processes were nonspontaneous in
nature.