Investigation of the Effect of Various Additives on the Clouding Behavior and Thermodynamics of Polyoxyethylene (20) Sorbitan Monooleate in Absence and Presence of Ceftriaxone Sodium Trihydrate Drug

Self Cite

Cloud point (CP) measurements of 4‐(1,1,3,3‐tetramethylbutyl) phenyl‐polyethyleneglycol (Triton X‐100 (TX‐100)) were performed in aqueous solution in the presence of drug Amikacin sulfate (AS)/Neomycin sulfate (NS)/(AS/NS+ different inorganic salts). In aqueous solution, the CP values of TX‐100 first decrease with increasing concentration and then increase with increasing surfactant concentration. The CP values of TX‐100 solutions were found to increase with the increasing concentration of the AS/NS drug. The CP values of TX‐100‐AS/NS mixtures were also observed to decrease with the increase of the concentration of salt. Different thermodynamic parameters such as standard free energy (normalΔGc0), standard enthalpy (normalΔHc0) as well as the standard entropy (normalΔSc0) change of phase separation were calculated and discussed in relation to molecular interactions.

Section: Resultssupporting

confidence: 92%

“…On the other hand, values of

normalΔ S_{c}^{0}

normalΔ H_{c}^{0}

in water are due to disruption of the H 2 O structure in the hydrophobic portion of the amphiphilic molecules (Naqvi et al, ).…”

Section: Resultssupporting

confidence: 88%

Effect of Various Electrolytes on the Phase Separation and Thermodynamic Properties of p‐Tert‐Alkylphenoxy Poly (Oxyethylene) Ether in the Absence/Presence of Drugs

Amin

Mahbub

Alam

et al. 2019

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“…The variation of CP of aqueous TX‐100 as a function of its concentration has been studied and observed to be decreased with the increase of its concentration (Table and Fig. ) such observation of CP values of nonionic surfactant was also described earlier (Rahman et al, ). The reduction of CP in aqueous medium is probably due to large reduction in the micellar aggregation number ( N agg ) of the TX‐100 and increased intermicellar interaction.…”

Section: Resultssupporting

confidence: 68%

“…The free energy of transfer (

{∆ G}_{normalm, tr}^{o}

), enthalpy of transfer (

{∆ H}_{normalm, tr}^{o}

), and entropy of transfer (

{∆ S}_{normalm, tr}^{o}

) micelles from pure TTAB in an aqueous medium to TTAB+additives were obtained using the following relations (Rahman et al, ; Shivaji and Rakshit, ):

{∆ G}_{normalm, tr}^{o} = {∆ G}_{m}^{o} ((), aq . additive) - {∆ G}_{m}^{o} ((), aq .)

{∆ H}_{normalm, tr}^{o} = {∆ H}_{m}^{o} ((), aq . additive) - {∆ H}_{m}^{o} ((), aq .)

{∆ S}_{normalm, tr}^{o} = {∆ S}_{m}^{o} ((), aq . additive) - {∆ S}_{m}^{o} ((), aq .)

…”

Section: Resultsmentioning

confidence: 99%

Influence of Different Additives on the Interaction of Quinolone Antibiotic Drug with Surfactant: Conductivity and Cloud Point Measurement Study

Rahim

Mahbub

Islam

et al. 2019

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Conductometric and cloud point (CP) measurement studies have been performed to investigate the interaction of tetradecyltrimethylammonium bromide (TTAB) and Triton® X‐100 (TX‐100) with ciprofloxacin hydrochloride (CFH) in different solvents over the temperature range of 295.15–315.15 K. CFH is used for the treatment of various bacterial infections. The observed critical micelle concentration (CMC) values of TTAB were found to be reduced in the presence of electrolytes (Na2SO4/Na3PO4), and this reduction proceeds with the elevation of salt concentration. The order of the CMC of TTAB follows the trend: cmcH2normalO > cmcNa3PO4 >cmcNa2SO4. The observed CMC values of TTAB were found to increase with increasing temperature and decrease with increasing concentration of CFH in aqueous medium. The values of Gibbs free energy of micellization (∆Gmo) for the TTAB/TTAB + CFH mixture were found to be negative, implying spontaneous micellization. The estimated CP of TX‐100 decreases with increasing concentration of TX‐100 in aqueous medium. The CP values first decrease with increasing concentration of CFH and then increase at higher concentration of CFH almost in all cases investigated. The values of free energy of clouding were found to be positive in all cases studied implying that phase separation of TX‐100 was nonspontaneous. The other thermodynamic parameters associated with the micellization of TTAB and the phase separation of TX‐100 were estimated and explained.

“…Over the past few decades, the study of interactions between surfactants and/or surfactants and drugs has attracted considerable interest in the fundamental and applied research arenas (Huang & Ren, ; James‐Smith, Shekhawat, Moudgil, & Shah, ; Kumar, Rub, Akram, & Kabir‐ud‐Din, ; Rahman, Khan, Rub, Hoque, & Asiri, ; Rub, Azum, & Asiri, ). This is due to widespread use of surfactants in various pharmaceutical formulations.…”

Section: Introductionmentioning

confidence: 99%

Conductometric Probe Analysis of the Effect of Benzyldimethylhexadecylammonium Chloride on the Micellization Behavior of Dodecyltrimethylammonium Bromide in Aqueous/Urea Solution: Investigation of Concentration and Temperature Effect

Molla

Rana

Rub

et al. 2018

Self Cite

Surfactant mixtures are used in many different industrial formulations. In this study, the mixed micelle formation behavior of 2 different cationic surfactants, namely dodecyltrimethylammonium bromide (DTAB) and benzyldimethylhexadecylammonium chloride (BDHAC), in the absence and presence of urea at various temperatures (298.15–318.15 K) was studied using the conductometric method. The attractive interaction between DTAB and BDHAC was estimated from the values of critical micelle concentration (CMC) and the CMC for ideal mixing (CMCid). Urea increases the CMC value as a result of the enrichment in the surface charge of the micelles/mixed micelles. The values of micellar mole fraction (X1Rub [Rubingh], X1M [Motomura], X1Rod [Rodenas]) and ideal micellar (X1id) of surfactant BDHAC were obtained by different models and are shown to exhibit the high contribution or effective involvement of BDHAC in mixed micelles and increase with increasing BDHAC mole fraction (α1). Activity coefficients (f1 and f2) were also evaluated from the relevant formula given in the literature. The negative values of the interaction parameters (β) show the attractive interaction among the studied components. Excess Gibbs free energy (∆Gex) of micellization revealed that the stability of mixed micelles is higher in aqueous solution than in urea solution. The thermodynamic parameters, namely the Gibbs free energy change, enthalpy change, and entropy change (∆Gom, ΔHom, and ∆Som, respectively), were also calculated from the conventional standard equations.