An endoscopic wireless gastrostimulator (with video)

Deb, Sanchali; Tang, Shou Jiang; Abell, Thomas L.; Rao, Smitha; Huang, Wendeng; To, S. D. Filip; Lahr, Christopher J.; Chiao, J.-C.

doi:10.1016/j.gie.2011.09.052

Cited by 44 publications

(31 citation statements)

References 12 publications

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“…Deb et al 85 developed a novel, wirelessly powered miniature gastric electrical stimulation device implanted into the pig stomach through an over-tube and attached to the gastric mucosa with endoclips. 86 Electrogastrogram recordings have demonstrated more consistent gastric slow wave amplitudes compared to with no stimulation. The method still needs to be deployed and validated in humans.…”

Section: Gastric Electrical Stimulationmentioning

confidence: 98%

Novel Diet, Drugs, and Gastric Interventions for Gastroparesis

Camilleri

2016

Clinical Gastroenterology and Hepatology

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This review of the pathophysiological basis for gastroparesis and recent advances in the treatment of patients with gastroparesis shows that there are several novel approaches to advance treatment of gastroparesis including diet, novel prokinetics, interventions on the pylorus, and novel forms of gastric electrical stimulation. The field of gastroparesis is likely to advance with further studies, with the help from a guidance document from the FDA on gastroparesis, and with the recent approval of the stable isotope gastric emptying test to ensure eligibility of participants in multicenter trials. Clinical experience and a formal, randomized, controlled trial provide insights on optimizing dietary interventions in patients with gastroparesis. This review addresses the biological rationale of these different treatments, based on known physiology and pathophysiology of gastric emptying. The novel medications include the motilin agonist, camicinal, 5-HT4 receptor agonists such as velusetrag, and the ghrelin agonist, relamorelin. New approaches target pylorospasm by either stent placement, endoscopic pyloric myotomy or laparoscopic pyloroplasty. These approaches offer the opportunity to achieve more permanent reduction of resistance to flow at the pylorus over the intrapyloric injection of botulinum toxin, which typically has to be repeated every few months if it is efficacious. A novel device, deployed in porcine stomach, involved per-endoscopic electrical stimulation. These promising approaches require formal, randomized, controlled trials and deployment in patients. The presence of concomitant antral hypomotility may be a significant factor in the responsiveness to interventions at the pylorus.

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Section: Gastric Electrical Stimulationmentioning

confidence: 98%

Novel Diet, Drugs, and Gastric Interventions for Gastroparesis

Camilleri

2016

Clinical Gastroenterology and Hepatology

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“…Most recently, feasibility of miniature wireless gastric stimulators positioned during endoscopy was demonstrated (Fig. 3) [45].…”

Section: Endoscopic and Surgical Treatmentsmentioning

confidence: 99%

“…The stimulator generates a pulse profile similar to that of the current implantable gastric stimulator for gastroparesis. From Figure 1 of Reference [45].…”

Section: Endoscopic and Surgical Treatmentsmentioning

confidence: 99%

Gastroparesis

Hasler¹

2012

Current Opinion in Gastroenterology

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“…However, no information was presented justifying the choice of material, and the device was removed after two hours in vivo, so that no information regarding long-term adhesion, or general efficiency of the protection method, could be deduced [5].…”

Section: Implant Packagingmentioning

confidence: 99%

Silicone rubber encapsulation for an endoscopically implantable gastrostimulator

Lonys

Vanhoestenberghe

Julemont

et al. 2015

Med Biol Eng Comput

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Gastrointestinal stimulator implants have recently shown positive results in treating obesity. However, the implantation currently requires an invasive surgical procedure. Endoscopy could be used to place the gastric stimulator in the stomach, hence avoiding the riskier surgery. The implant then needs to go through the oesophagus and be located inside the stomach, which imposes new design constraints, such as miniaturization and protecting the electronic circuit against the highly acidic environment of the stomach. We propose to protect the implant by encapsulation with silicone rubber. This paper lists the advantages of this method compared to the more usual approach of a hermetic enclosure and then presents a method to evaluate the underwater adhesive stability of six adhesive/substrate couples, using repeated lap-shear tests and an elevated temperature to accelerate the ageing process. The results for different adhesive/substrate couples tested, presented on probability plots, show that FR4 and alumina substrates with MED4-4220 silicone rubber are suitable for a first implantable prototype. We then compare these with the predicted lifetimes of bonds between historical standard silicone rubber DC3140 and different substrates and describe the encapsulation of our gastrostimulator.

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An endoscopic wireless gastrostimulator (with video)

Cited by 44 publications

References 12 publications

Novel Diet, Drugs, and Gastric Interventions for Gastroparesis

Novel Diet, Drugs, and Gastric Interventions for Gastroparesis

Gastroparesis

Silicone rubber encapsulation for an endoscopically implantable gastrostimulator

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