1986
DOI: 10.1016/0024-3205(86)90248-1
|View full text |Cite
|
Sign up to set email alerts
|

An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
60
2

Year Published

1989
1989
2015
2015

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 134 publications
(62 citation statements)
references
References 13 publications
0
60
2
Order By: Relevance
“…Pharmacologic characterization by binding assays confirmed the existence of a population of imidazoline-specific binding sites that are insensitive to catecholamines in the brainstem RVLM of animals and man (2,5,6). These studies clearly demonstrated that imidazoline binding sites are distinct from α2-adrenoceptors.…”
Section: Discovery Of Imidazoline Receptorsmentioning
confidence: 68%
“…Pharmacologic characterization by binding assays confirmed the existence of a population of imidazoline-specific binding sites that are insensitive to catecholamines in the brainstem RVLM of animals and man (2,5,6). These studies clearly demonstrated that imidazoline binding sites are distinct from α2-adrenoceptors.…”
Section: Discovery Of Imidazoline Receptorsmentioning
confidence: 68%
“…The assumption that there are non-adrenergic receptors sensitive to imidazolines was based on these data. Since then, binding studies have suggested the existence of speci®c binding sites for imidazoline compounds, which are insensitive to catecholamines (Bricca et al, 1989;Meeley et al, 1986). These imidazoline binding sites (IBS) have been classi®ed in two main subtypes (Michel & Insel, 1989).…”
Section: Introductionmentioning
confidence: 99%
“…both in bovine and human brain (Ernsberger et al, 1987;Bricca et al, 1988;1989a). An endogenous ligand for this receptor has been partially purified (Atlas & Burnstein, 1984a,b;Meeley et al, 1986;Ernsberger et al, 1988). In fact, a partially purified brain extract contains a substance which is not a catecholamine but displaces [3H]-clonidine bound to brain membrane preparations and increases blood pressure whereas clonidine itself reduces it (Atlas & Burstein, 1984a,b;Bousquet et al, 1986).…”
Section: Introductionmentioning
confidence: 99%