An elevated level of BNP in plasma is related to the development of good collateral circulation in coronary artery disease

Xi, Weiwei; Cheng, Gang; Lv, Shumin; Gao, Qingzhu; Bu, Gang; Zhou, Ying; Xu, Geng

doi:10.1177/1741826710389556

Cited by 5 publications

(8 citation statements)

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“…26,27 Although BNP is associated with myocardial ischemia, there is a discrepancy in the study of Xi et al about the relationship between CCC and NT-proBNP. 25 According to their interpretation, they explained this discrepancy with the collateral formation, which had a complex role on prognosis in CAD patients. On the other hand, BNP was recently demonstrated to be a potential stimulator of angi-ogenesis and arteriogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score

et al. 2014

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Section: Discussionmentioning

confidence: 99%

“…Up to now, only one study investigated the relationship between CCC and BNP. 25 They reported that elevated plasma BNP level was independently associated with CCC. 25 But, contrary to our study, patients with well-developed collaterals tended to have a higher BNP level.…”

Section: Discussionmentioning

confidence: 99%

Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score

et al. 2014

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“…On the other hand, in another study BNP levels were found to be significantly higher in patients with well-developed coronary collaterals and this result was explained by the potential triggering effect of BNP on angiogenesis. 10 Inconsistency between the results could be explained by the difference between study populations and definitions used to describe CCC status. In our study well-developed CC group was composed of only Rentrop grade 3 collaterals.…”

Section: Discussionmentioning

confidence: 99%

“… 7 There are conflicting data regarding effect of collaterals on natriuretic peptide levels. 8 , 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Influence of collaterals on the left ventricular end-diastolic pressure and serum NT-proBNP levels in patients with coronary chronic total occlusion

Samadov

Yeşildağ

Sarı

et al. 2017

The Egyptian Heart Journal

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ObjectiveAlthough numerous studies have shown the protective effects of the well-developed coronary collaterals on left ventricular functions, the relationship between collateral grade and left ventricular end diastolic pressure has not been studied in chronic total occlusion patients. Also, there are conflicting data on the effect of collaterals on NT-proBNP levels. The aim of our study was to evaluate the relationship between coronary collateral circulation and left ventricular end diastolic pressure and NT-proBNP levels in chronic total occlusion patients.MethodsStudy group was retrospectively selected from the patients who had undergone coronary angiography at our hospital between June 2011 and March 2013. Clinical, biochemical, angiographic and hemodynamic data of 199 consecutive patients having at least one totally occluded major epicardial coronary artery were evaluated. Coronary collateral circulation was graded according to Rentrop classification. While Rentrop grade 3 was defined as well-developed, all the remaining collateral grades were regarded as poor collaterals.ResultsOverall 87 patients were found to have good collaterals and 112 patients had poor collaterals. There was no significant difference between the patients with well- or poorly developed coronary collaterals with regard to left ventricular end diastolic pressure (16.84 ± 5.40 mmHg vs 16.10 ± 6.09, respectively, p = 0,632) and log NT-proBNP (2.46 ± 0.58 vs 2.59 ± 0.76, respectively, p = 0,335).ConclusionIn patients with coronary chronic total occlusion even well-developed coronary collaterals are not capable of protecting the rise of left ventricular end diastolic pressure and NT-proBNP levels which are reliable markers of the left ventricular dysfunction.

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“…Thus, this work aimed to determine whether part of the cardioprotective effect of BNP treatment in infarcted hearts relates to increased neovascularisation, since high BNP levels in plasma are associated with increased collateral development in patients with coronary artery disease 28 .…”

Section: Introductionmentioning

confidence: 99%

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1⁺epicardium-derived cells

Rignault-Clerc

Bielmann

et al. 2020

Preprint

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Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction. Here, we investigated whether part of the cardioprotective effect of BNP in infarcted hearts related to improved neovascularisation. Infarcted mice were treated with saline or BNP for 10 days. BNP treatment increased vascularisation and the number of endothelial cells in the infarct border and remote zones of infarcted hearts. Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident mature endothelial cells in both areas of the infarcted hearts, via NPR-A binding and p38 MAP kinase activation. BNP also stimulated the proliferation of WT1+ epicardium-derived cells but only in the hypoxic area of infarcted hearts. Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. BNP treatment increased their proliferation but not their differentiation capacity. We identified new roles for BNP and new therapeutic strategies to improve heart recovery in infarcted hearts.

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An elevated level of BNP in plasma is related to the development of good collateral circulation in coronary artery disease

Abstract: An elevated level of BNP in plasma is independently associated with collateral development; patients with good collaterals tend to have a higher BNP level.

Cited by 5 publications

References 20 publications

Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score

Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score

Influence of collaterals on the left ventricular end-diastolic pressure and serum NT-proBNP levels in patients with coronary chronic total occlusion

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1⁺epicardium-derived cells

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An elevated level of BNP in plasma is related to the development of good collateral circulation in coronary artery disease

Abstract: An elevated level of BNP in plasma is independently associated with collateral development; patients with good collaterals tend to have a higher BNP level.

Cited by 5 publications

References 20 publications

Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score

Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score

Influence of collaterals on the left ventricular end-diastolic pressure and serum NT-proBNP levels in patients with coronary chronic total occlusion

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1+epicardium-derived cells

Contact Info

Product

Resources

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Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1⁺epicardium-derived cells