Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score

Abstract

Cardiac risk markers, such as NT-proBNP, hs-cTnT and hs-CRP are independently associated with CCC in stable coronary artery disease with chronic total occlusion.

The Association between Whole Blood Viscosity and Coronary Collateral Circulation in Patients with Chronic Total Occlusion

“…Atherosclerotic plaque localizations have a linear relation with the blood viscosity that frequent plaque formation were observed among the higher viscosity regions especially in the proximal segments of the coronary arteries 22). Börekçi et al observed higher SYNTAX scores in patients with poor CCC 20). Similarly, we observed that in the poor CCC group, SYNTAX scores were significantly higher compared to good CCC group.…”

“…Angiogenesis (new vessel formation) and/or arteriogenesis (growth of preexisting arterioles) result in the CCC development. Although, in the previous reports, the role of hemorheological and biochemical factors in the development CCC has been recognized,19)20) the effect of the WBV on CCC has not been studied well. The present study showed that patients with poor CCC had significantly higher WBV values for both shear rates compared to the good collateral group, and higher WBV was an independent predictor for poor CCC.…”

Relation of platelet indices to severity of coronary artery disease in patients undergoing primary percutaneous coronary intervention

“…22 Recently, MPV has not been found to be associated with coronary collateral circulation in stable CAD with chronic total occlusion. 23 Plateletcrit is a measure of total platelet mass (PCT = platelet count × MPV / 10 7 ). Recently, the prognostic role of the plateletcrit was shown in 2572 STEMI patients undergoing PPCI.…”

Non-infarct related chronically occluded coronary arteries and its association with diabetes and prediabetes

“…28 The diabetic pathophysiology promotes an anti-angiogenic process and meanwhile mitigates pro-angiogenic factors in coronary vasculature during ischemia, jointly leading to impaired collateral growth. 28,29 Although the influence of the DM on collateral development is debatable, 11,[30][31][32][33][34] it has been reported that diabetics and prediabetics generally have a poor acute collateral response because of the diffusely impaired endothelial function, [35][36][37] particularly in the presence of active smoking. 5,38,39 Whereas the DM and prediabetes aggressively induces atherosclerosis and may be more susceptible to infarction; they can also activate some endogenous cardioprotective mechanisms protecting the left ventricular contractile function.…”