An elemental correlation study in cancerous breast tissue by total reflection x-ray fluorescence

Majewska, U.; Braziewicz, J.; Banaś, D.; Kubala‐Kukuś, A.; Góźdż, Stanisław; Pajek, M.; Smok, Jolanta; CJrbaniak, Antoinette

doi:10.1007/bf02783312

Cited by 43 publications

(39 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Slightly higher Pb levels in the malignant breast tissues compared with the normal tissues have been reported in a US study [32]. Majewska et al [16] have reported enhanced concentrations of many trace elements in malignant breast tissues and suggested that these elements compete for the binding sites in the cell, change its enzymatic activity, and exert direct or indirect action on the carcinogenic processes, accelerating the growth of tumors, and that the inhibition of enzymes caused by the variation in trace element concentrations results in the immunological breakdown of the body system.…”

Section: Resultsmentioning

confidence: 91%

“…Epidemiological studies showed that the majority of the factors leading to the development of malignant tumor in humans have arisen from environmental factors including the work environment, followed by nutritional habits as well as viral attacks and only meagerly as consequences of genetic predispositions [14,15]. Several studies have focused on the relationship between trace metal and breast cancer in humans, which indicated that the trace metals may influence the carcinogenic process [16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Pasha

Malik

Iqbal³

et al. 2008

Biol Trace Elem Res

View full text Add to dashboard Cite

Selected trace metals were analyzed in human malignant and nonmalignant (benign) breast tissue samples by the flame atomic absorption spectrophotometric method. In malignant tissues, dominant mean concentrations were revealed by Na, K, Ca, Mg, Fe, Zn, and Al at 927, 552, 231, 61.7, 36.5, 18.3, and 8.94 microg/g, respectively, while the mean metal levels in benign tissues were 903, 435, 183, 63.3, 24.7, 14.5, and 10.1 microg/g, respectively. Average concentrations of Cd, Co, Cr, Cu, Fe, Mn, K, Ca, and Zn were noted to be significantly higher in the malignant tissues compared with the benign tissues. Significantly strong correlations (r > 0.50) in malignant tissues were observed between Mn and Co, Mn and Cd, Cd and Cr, Fe and Mn, Cd and Co, Fe and Co, Mg and Pb, Cd and Fe, Mg and Ni, Pb and Ni, Ni and Sr, and Fe and Pb, whereas, Cd and Co, Cd and Mn, Co and Mg, Co and Mn, Cu and Mn, Co and Ni, Mg and Ni, Cd and Cu, Cd and Ni, Ca and Mg, Mn and Pb, Cu and Ni, Fe and Ni, Cd and Mg, Co and Cu, Cr and Na, and Cd and Cr revealed strong and significant relationships in benign tissues at p < 0.001. Principal component analysis of the metals data yielded six principal components for malignant tissues and five principal components for benign tissues, with considerably different loadings, duly supported by cluster analysis. The study revealed a considerably different pattern of distribution and mutual correlations of trace metals in the breast tissues of benign and cancerous patients.

show abstract

Section: Resultsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Pasha

Malik

Iqbal³

et al. 2008

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Garg et al (1994) and Ng et al (1997) utilised Neutron Activation Analysis (NAA) to study paired breast tissue specimens (healthy and tumours), while the same technique was employed by Kanias et al (1994) to compare samples of fibrocystic disease and fibroadenoma (benign breast tumour). X-Ray Fluorescence (XRF) has been used by Rizk and Sky-Peck (1984) to study paired samples, while Total Reflection XRF was utilised by Majewska et al (1997) to compare benign to malignant breast tumours. More recently studies by our group have shown statistically significant changes in levels of copper, iron, zinc and potassium in breast tissue, these changes being associated with cancer (Geraki et al 2002, Geraki et al 2004.…”

Section: Introductionmentioning

confidence: 99%

The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF system

Farquharson

Geraki

Falkenberg

et al. 2007

Applied Radiation and Isotopes

View full text Add to dashboard Cite

Trace elements have critical roles in cancer biology. The quantity and the distribution of the elements Cl, Ca, K, P, S, Ti, Fe, Cu and Zn in samples of primary breast cancer has been assessed. The samples were formalin fixed tissue specimens formatted as microarrays of cores 1.0 mm diameter and 10µm thick each. The data were obtained using a synchrotron X-Ray Fluorescence Microprobe system. The spatial resolution of elemental maps was approximately 20µm. Maps were compared with light transmission images of the samples and images of the samples stained for cancer. The synchrotron system proved successful in producing data that could be mapped into high resolution images where clear structure could be identified. Correlation of these distributions with the concentrations of cancer cells was achieved in some samples.

show abstract

“…Enhancement of trace elements in the scalp hair of breast cancer patients suggested that these elements compete for the binding sites in the cell, change its enzymatic activity, and exert direct or indirect action on the carcinogenic progress, accelerating the growth of tumors. The inhibition of enzymes caused by variation in trace element concentrations may result in immunological breakdown of the body system [35]. The quartile distribution of selected elements in the scalp hair of three donor groups is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Trace Elements in the Scalp Hair of Malignant and Benign Breast Lesions Versus Healthy Women

Pasha

Malik

Shaheen

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

Trace elements including Al, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Sb, Sr, and Zn were analyzed in the scalp hair samples of women with malignant breast lesions, women with benign breast lesions, and healthy donors using atomic absorption spectrophotometric method. In the scalp hair of malignant-tumor patients, the highest average concentration was shown by Ca (1,187 microg/g), followed by Na (655 microg/g), Mg (478 microg/g), Zn (391 microg/g), Sr (152 microg/g), Fe (114 microg/g), and K (89.8), while in the case of benign-tumor patients, the average estimated element levels were 1,522, 1,093, 572, 457, 217, 80.4, and 74.7 microg/g, respectively. Most of the elements exhibited non-normal distribution evidenced by large spread, standard error, and skewness values. Mean concentrations of Ca (634 microg/g), Zn (206 microg/g), Mg (162 microg/g), Fe (129 microg/g), and Na (82.1 microg/g) were noteworthy in the scalp hair of healthy women. Average levels of Na, Sr, K, Cd, Co, Pb, Mg, Ca, Zn, Ni, Sb, and Mn were revealed to be significantly higher in the hair of malignant and benign patients compared to the healthy women; however, Fe, Cu, Al, and Cr were not significantly different in the scalp hair of the three groups. The quartile distributions of Ca, Cd, Co, Cr, K, Mg, Mn, Na, Ni, Pb, Sb, and Sr revealed maximum spread in the scalp hair of malignant and benign groups; nevertheless, Al, Cu, Fe, and Zn exhibited almost comparable quartile levels in the three groups. Strong correlation coefficients were found between Fe and Cd, Al and Na, Mn and Sr, Co and Cr, Cd and Cr, Pb and K, Pb and Mn, Cu and Na, and Al and Fe in the scalp hair of malignant-tumor patients, while Fe and K, Cd and Co, Na and Co, and Cr and Pb showed strong correlations in the scalp hair of benign-tumor patients, both of which were significantly different compared with the healthy subjects. Multivariate cluster analysis also revealed divergent clustering of the elements in the scalp hair of malignant and benign patients in comparison with the healthy women.

show abstract

An elemental correlation study in cancerous breast tissue by total reflection x-ray fluorescence

Cited by 43 publications

References 14 publications

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF system

Comparison of Trace Elements in the Scalp Hair of Malignant and Benign Breast Lesions Versus Healthy Women

Contact Info

Product

Resources

About