An electrophysiological and immunohistochemical study of the hippocampus of the reeler mutant mouse

Ishida, Akihiro; Shimazaki, Kuniko; Terashima, Toshio; Kawai, Nobufumi

doi:10.1016/0006-8993(94)90795-1

Cited by 20 publications

(16 citation statements)

References 27 publications

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“…Whilst available data are limited, silver staining appears to show a narrow plexus of axons in the stratum lacunosum-moleculare of reeler (Stanfield and Cowan, 1979), and immunocytochemistry for the F3/F11 cell adhesion molecule shows a prominent axon bundle at the hippocampal fissure (Ishida et al, 1994). These tracts may represent the equivalent of the dense fascicle of neurofilament-positive axons that we observed in this position in SRK.…”

Section: Discussionmentioning

confidence: 77%

Laminar boundaries persist in the hippocampal dentate molecular layer of the mutant Shaking Rat Kawasaki despite aberrant granule cell migration

Woodhams¹,

Terashima

1999

J. Comp. Neurol.

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Section: Discussionmentioning

confidence: 77%

Laminar boundaries persist in the hippocampal dentate molecular layer of the mutant Shaking Rat Kawasaki despite aberrant granule cell migration

Woodhams¹,

Terashima

1999

J. Comp. Neurol.

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“…With regard to interneurons characterized by the presence of parvalbumin, the innervation of the two pyramidal cell layers in reeler mice does not show gross differences (Fig. 3e, Ishida et al 1994). That inhibitory mechanisms of deep and superficial pyramidal cells may differ is supported by the selective vulnerability of superficial cells to focal injections of low doses of γ-acetylenic GABA (Goodman 1998), an indirect excitotoxin, which attenuates the formation of kynurenate and GABA and which produces selective cell death also in other parts of the hippocampal formation (Wu and Schwarcz 1998).…”

Section: Connectivitymentioning

confidence: 91%

“…Alternatively, extrinsic factors, such as spatial barriers set up by ingrowing afferents (Ishida et al 1994; Deller et al 1999), may be responsible. Cell-intrinsic factors would per se distinguish the two populations.…”

Section: Developmentmentioning

confidence: 99%

Hippocampal pyramidal cells: the reemergence of cortical lamination

et al. 2011

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The increasing resolution of tract-tracing studies has led to the definition of segments along the transverse axis of the hippocampal pyramidal cell layer, which may represent functionally defined elements. This review will summarize evidence for a morphological and functional differentiation of pyramidal cells along the radial (deep to superficial) axis of the cell layer. In many species, deep and superficial sublayers can be identified histologically throughout large parts of the septotemporal extent of the hippocampus. Neurons in these sublayers are generated during different periods of development. During development, deep and superficial cells express genes (Sox5, SatB2) that also specify the phenotypes of superficial and deep cells in the neocortex. Deep and superficial cells differ neurochemically (e.g. calbindin and zinc) and in their adult gene expression patterns. These markers also distinguish sublayers in the septal hippocampus, where they are not readily apparent histologically in rat or mouse. Deep and superficial pyramidal cells differ in septal, striatal, and neocortical efferent connections. Distributions of deep and superficial pyramidal cell dendrites and studies in reeler or sparsely GFP-expressing mice indicate that this also applies to afferent pathways. Histological, neurochemical, and connective differences between deep and superficial neurons may correlate with (patho-) physiological phenomena specific to pyramidal cells at different radial locations. We feel that an appreciation of radial subdivisions in the pyramidal cell layer reminiscent of lamination in other cortical areas may be critical in the interpretation of studies of hippocampal anatomy and function.

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“…Since dendritic arborization is closely coupled to synaptogenesis [3], the misorientation of a neuron may result in dendritic abnormalities. Indeed, reeler hippocampal pyramidal neurons, which are severely misoriented and make poor connections with target cells [2,16], have short and poorly branched dendrites. Why are neurons misoriented in reeler?…”

Section: Neurons Only Need To Receive a Small Amount Of The Reelin-damentioning

confidence: 99%

Hippocampal dendritic arbor growth in vitro: Regulation by Reelin–Disabled-1 signaling

Maclaurin¹,

Krucker²,

Fish³

2007

Brain Research

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The cytoplasmic adaptor protein Disabled-1 (Dab1), which is a key component of the Reelinsignaling pathway, has been suggested to be required for neuronal dendritic development. However, only data from studies on immature cultures [≤ 6 days in vitro (DIV)] and cytoarchitectural analyses of mutant mice have been used to formulate this hypothesis. Therefore, to determine if Reelin-Dab1 signaling is specifically required for neurons to develop mature dendrites in respect to length and complexity we analyzed dendritic development in mature cultures derived from Dab1 knockout (ko) embryos. No significant differences in dendritic length or complexity between Dab1 ko and wt cultures were found at 20 DIV. An examination of dendritic development in maturing cultures found significant differences in dendritic length between mutant and wt cultures at 4 DIV, but detected no differences in complexity. In addition, by 7 DIV all measures were statistically the same between cultures. Therefore, although Reelin-Dab1 signaling promotes hippocampal dendrite development, Dab1 is not required for neurons to reach maturity with respect to dendritic length and complexity. Furthermore, analyses of 4 DIV cultures derived from Dab1 heterozygotes or mice that express only the natural splice form of Dab1 (p45) found that Dab1 p45/− hemizygote, but not Dab1 p45/p45 and Dab1 heterozygote cultures had significantly shorter dendrites than those in wt cultures. Thus, a substantial attenuation of the Reelin-Dab1 signal is required before dendrite elongation is significantly decreased at 4 DIV. Moreover, experiments that incorporated a Reelin-neutralizing antibody support the hypothesis that the role(s) Reelin-signaling plays in dendritic maturation is different than the one it has in neuronal positioning.

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An electrophysiological and immunohistochemical study of the hippocampus of the reeler mutant mouse

Cited by 20 publications

References 27 publications

Laminar boundaries persist in the hippocampal dentate molecular layer of the mutant Shaking Rat Kawasaki despite aberrant granule cell migration

Laminar boundaries persist in the hippocampal dentate molecular layer of the mutant Shaking Rat Kawasaki despite aberrant granule cell migration

Hippocampal pyramidal cells: the reemergence of cortical lamination

Hippocampal dendritic arbor growth in vitro: Regulation by Reelin–Disabled-1 signaling

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