“…An earlier study using retrograde horseradish peroxidase (HRP) tracing demonstrated clearly that corticospinal neurons, which are located only in layer V in the motor cortex of the normal rat, were distributed widely from the pial surface to the white matter in the corresponding cortical areas of the SRK rat (Ikeda and Terashima, 1997). In the hippocampus, all laminar structures are also disrupted (Aikawa et al, 1988; Woodhams and Terashima, 1999, 2000), although despite the abnormal cytoarchitecture, entorhinal axons are able to find their appropriate target field in the dentate molecular layer (Woodhams and Terashima, 1999, 2000). These morphological abnormalities in the laminated structures, including the cerebral and cerebellar cortices and hippocampus, resemble those reported in the reeler mutant mouse which is associated with an autosomal recessive mutation of the reelin gene encoding the Reelin protein (Caviness and Rakic, 1978; Goffinet, 1984a, 1990; D'Arcangelo and Curran, 1998; Pearlman et al, 1998; Bar et al, 2000; Gleeson and Walsh, 2000).…”