Laminar boundaries persist in the hippocampal dentate molecular layer of the mutant
            <i>Shaking Rat Kawasaki</i>
            despite aberrant granule cell migration

Woodhams, P.L.; Terashima, Toshio

doi:10.1002/(sici)1096-9861(19990621)409:1<57::aid-cne5>3.0.co;2-#

Cited by 12 publications

(18 citation statements)

References 42 publications

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“…Motoneurons located in the facial, motor trigeminal, and ambiguus nuclei were distributed more widely in the SRK rat than in their normal counterparts. Taken together with previous studies (Aikawa et al, 1988; Fujii et al, 1994; Ikeda and Terashima, 1997; Woodhams and Terashima, 1999), the present report has confirmed that the SRK rat is a reeler ‐phenotype mutant rat, although some differences between these two mutant strains were also apparent.…”

Section: Discussionsupporting

confidence: 91%

“…The SRK rat is characterized by body shaking, ataxic‐paretic gait, dystonic posture, and tremor. Previous histological studies of the SRK rat showed that laminated structures such as the cerebral and cerebellar cortex and hippocampus are severely affected (Aikawa et al, 1988; Fujii et al, 1994; Ikeda and Terashima, 1997; Woodhams and Terashima, 1999, 2000). For example, the cerebellum is reduced in size and no cerebellar foliation is observed.…”

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confidence: 98%

“…An earlier study using retrograde horseradish peroxidase (HRP) tracing demonstrated clearly that corticospinal neurons, which are located only in layer V in the motor cortex of the normal rat, were distributed widely from the pial surface to the white matter in the corresponding cortical areas of the SRK rat (Ikeda and Terashima, 1997). In the hippocampus, all laminar structures are also disrupted (Aikawa et al, 1988; Woodhams and Terashima, 1999, 2000), although despite the abnormal cytoarchitecture, entorhinal axons are able to find their appropriate target field in the dentate molecular layer (Woodhams and Terashima, 1999, 2000). These morphological abnormalities in the laminated structures, including the cerebral and cerebellar cortices and hippocampus, resemble those reported in the reeler mutant mouse which is associated with an autosomal recessive mutation of the reelin gene encoding the Reelin protein (Caviness and Rakic, 1978; Goffinet, 1984a, 1990; D'Arcangelo and Curran, 1998; Pearlman et al, 1998; Bar et al, 2000; Gleeson and Walsh, 2000).…”

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confidence: 99%

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Branchiogenic motoneurons innervating facial, masticatory, and esophageal muscles show aberrant distribution in the reeler‐phenotype mutant rat, Shaking Rat Kawasaki

Setsu

Ikeda

Woodhams³

et al. 2001

J of Comparative Neurology

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Shaking Rat Kawasaki (SRK) is an autosomal recessive mutant rat that is characterized by cerebellar ataxia. Although previous studies indicated many points of similarity between this mutant rat and the reeler mouse, nonlaminated structures such as the facial nucleus have not been studied in this mutant rat. Nissl-stained sections through the brainstem showed that the cytoarchitecture of the facial, motor trigeminal, and ambiguus nuclei was abnormal in SRK, especially in the lateral cell group of the facial nucleus and the compact formation of the ambiguus nucleus. To examine whether orofacial motoneurons are also malpositioned in the SRK rat, horseradish peroxidase (HRP) was injected into the facial, masticatory, and abdominal esophageal muscles of the SRK rats and normal controls to label facial, trigeminal, and ambiguus motoneurons, respectively. HRP-labeled facial, trigeminal, and ambiguus motoneurons of the SRK rat were distributed more widely than those of their normal counterparts, as in the case of the reeler mouse, with the one exception that labeled facial motoneurons innervating the nasolabial muscle were distributed more widely in the ventrolateral-to-dorsomedial direction in comparison with those of the reeler mutant. These data demonstrate that nonlaminated structures in the brainstem of the SRK rat are affected severely, as is the case in the reeler mutant mouse.

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Section: Discussionsupporting

confidence: 91%

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confidence: 98%

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confidence: 99%

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Branchiogenic motoneurons innervating facial, masticatory, and esophageal muscles show aberrant distribution in the reeler‐phenotype mutant rat, Shaking Rat Kawasaki

Setsu

Ikeda

Woodhams³

et al. 2001

J of Comparative Neurology

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“…4F). Glial Fibrillary Acidic Protein (GFAP) immunostaining suggested that increased gliosis both in the reeler and SRK prevents penetration of the axons from the entorhinal cortex across the hippocampal fissure (Woodhams and Terashima 1999, 2000; Muraoka et al . 2007) (Fig.…”

Section: Morphological Alterations In the Central Nervous System Of Rmentioning

confidence: 99%

Developmental anatomy of reeler mutant mouse

Katsuyama

Terashima

2009

Dev Growth Differ

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The reeler mouse is one of the most famous spontaneously occurring mutants in the research field of neuroscience, and this mutant has been used as a model animal to understand mammalian brain development. The classical observations emphasized that laminar structures of the reeler brain are highly disrupted. Molecular cloning of Reelin, the gene responsible for reeler mutant provided insights into biochemistry of Reelin signal, and some models had been proposed to explain the function of Reelin signal in brain development. However, recent reports of reeler found that non-laminated structures in the central nervous system are also affected by the mutation, making function of Reelin signal more controversial. In this review, we summarized reported morphological and histological abnormalities throughout the central nervous system of the reeler comparing to those of the normal mouse. Based on this overview of the reeler abnormalities, we discuss possible function of Reelin signal in the neuronal migration and other morphological events in mouse development.

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“… Abstract The Shaking Rat Kawasaki (SRK) is a neurological mutant that exhibits abnormalities of cell migration and lamination, with many similarities to the mouse reeler mutant. We recently used lamina‐specific antibody staining to show that despite severe aberrations in the laminar organization of the SRK dentate gyrus, the entorhinal terminal field in the outer dentate molecular layer appeared relatively normal (Woodhams & Terashima, 1999, J. Comp. Neurol.…”

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Aberrant trajectory of entorhino‐dentate axons in the mutant Shaking Rat Kawasaki: a DiI‐labelling study

Woodhams

Terashima

2000

Eur J of Neuroscience

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The Shaking Rat Kawasaki (SRK) is a neurological mutant that exhibits abnormalities of cell migration and lamination, with many similarities to the mouse reeler mutant. We recently used lamina-specific antibody staining to show that despite severe aberrations in the laminar organization of the SRK dentate gyrus, the entorhinal terminal field in the outer dentate molecular layer appeared relatively normal (Woodhams & Terashima, 1999, J. Comp. Neurol. 409 p57). However, neurofilament immunostaining suggested that entorhino-dentate afferents take an abnormal trajectory in reaching their appropriate targets, the granule cells dendrites. In the present study, anterograde tracing with the carbocyanine dye 1, 1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) has been used to delineate directly the path that entorhinal axons take to the dentate gyrus, confirming that in SRK entorhinal axons do indeed reach their appropriate terminal fields in the molecular layer, with laminar segregation between projections from the lateral and medial entorhinal cortices. However, these fibres fail to cross the hippocampal fissure between the subiculum and the dentate gyrus, coursing instead parallel to it until they curve round the deepest point of the fissure in field CA3. Similar findings were seen in the murine reeler mutant. Insertion of DiI crystals into the entorhinal cortex of neonatal rats also retrogradely labelled the developmentally transient Cajal-Retzius cells at the hippocampal fissure; these survive for longer in SRK than in normal littermates. The presence of a marked astrogliosis at the SRK hippocampal fissure may play a part in determining the abnormal trajectory taken by entorhino-dentate afferents in this mutant.

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Laminar boundaries persist in the hippocampal dentate molecular layer of the mutant Shaking Rat Kawasaki despite aberrant granule cell migration

Cited by 12 publications

References 42 publications

Branchiogenic motoneurons innervating facial, masticatory, and esophageal muscles show aberrant distribution in the reeler‐phenotype mutant rat, Shaking Rat Kawasaki

Branchiogenic motoneurons innervating facial, masticatory, and esophageal muscles show aberrant distribution in the reeler‐phenotype mutant rat, Shaking Rat Kawasaki

Developmental anatomy of reeler mutant mouse

Aberrant trajectory of entorhino‐dentate axons in the mutant Shaking Rat Kawasaki: a DiI‐labelling study

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