An electronic nose may sniff out amyotrophic lateral sclerosis

Dragonieri, Silvano; Quaranta, Vitaliano Nicola; Carratù, Pierluigi; Ranieri, Teresa; Marra, Lorenzo; D'Alba, Giuseppina; Resta, Onofrio

doi:10.1016/j.resp.2016.06.005

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…More recently, ALS was also investigated and breath profiles from patients were moderately discriminated from healthy controls (CVA: 75%). 53 Finally, oral malodor was assessed, and an AUC of 0.879 was reached comparing control subjects and malodor patients. 43 This technology can be explored and investigated to diagnose several diseases.…”

Section: Other Diseasesmentioning

confidence: 99%

The electronic nose technology in clinical diagnosis: A systematic review

Farraia

Rufo

Paciência

et al. 2019

Porto Biomedical Journal

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Background: Volatile organic compounds (VOC) are end products of human metabolism (normal and disease-associated) that can be mainly excreted in breath, urine, and feces. Therefore, VOC can be very useful as markers of diseases and helpful for clinicians since its sampling is noninvasive, inexpensive, and painless. Electronic noses, or eNoses, provide an easy and inexpensive way to analyze gas samples. Thus, this device may be used for diagnosis, monitoring or phenotyping diseases according to specific breathprints (breath profile). Objective: In this review, we summarize data showing the ability of eNose to be used as a noninvasive tool to improve diagnosis in clinical settings. Methods: A PRISMA-oriented search was performed in PubMed and Cochrane Library. Only studies performed in humans and published since 2000 were included. Results: A total of 48 original articles, 21 reviews, and 7 other documents were eligible and fully analyzed. The quality assessment of the selected studies was conducted according to the Standards for Reporting of Diagnostic Accuracy. Airway obstructive diseases were the most studied and Cyranose 320 was the most used eNose. Conclusions: Several case-control studies were performed to test this technology in diverse fields. More than a half of the selected studies showed good accuracy. However, there are some limitations regarding sampling methodology, analysis, reproducibility, and external validation that need to be standardized. Additionally, it is urgent to test this technology in intend-to-treat populations. Thus, it is possible to think in the contribution of VOC analysis by eNoses in a clinical setting.

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Section: Other Diseasesmentioning

confidence: 99%

The electronic nose technology in clinical diagnosis: A systematic review

Farraia

Rufo

Paciência

et al. 2019

Porto Biomedical Journal

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“…VOCs have been found in feces, urine, headspace of microorganism cultures, and exhaled breath. The compounds have been associated with respiratory, urogenital, and neurological disease, as well as with malignancies of the lung, colorectal, and head and neck origin …”

Section: Introductionmentioning

confidence: 99%

Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study

et al. 2019

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Background The aim of this feasibility study was to assess the diagnostic performance of an electronic nose (e‐nose) as a noninvasive diagnostic tool in detecting locoregional recurrent and/or second (or third) primary head and neck squamous cell carcinoma (HNSCC) after curative treatment. Methods Using an e‐nose (Aeonose, The eNose Company, Zutphen, The Netherlands), breath samples were collected from patients after curative treatment of an HNSCC with a locoregional recurrence or second (or third) primary tumor (N = 20) and from patients without evidence of recurrent disease (N = 20). Analyses were performed utilizing artificial neural networking based on patterns of volatile organic compounds. Results A diagnostic accuracy of 83% was observed in differentiating follow‐up patients with locoregional recurrent or second (or third) primary HNSCC from those without evidence of disease. Conclusion This study has demonstrated the feasibility of using an e‐nose to detect locoregional recurrent and/or second (or third) primary HNSCC.

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“…Regarding E-noses, a commercial system containing several conducting polymers as sensor arrays (Cyranose 320 ® ), offered by Sensigent (California, USA), was employed in the screening of several diseases (breast and lung cancer [ 207 , 208 , 209 ], asthma [ 210 , 211 ], and amyotrophic lateral sclerosis [ 212 ], among others), identification of foodstuffs (rice, wines [ 213 ], and fruits [ 214 ]) and classification of road asphalt samples [ 215 , 216 ]. Additionally, fecal VOCs can be inspected as well, informing about the microbial enterotype of infants [ 217 ].…”

Section: Future Perspectives: Integration Of E-tongues and E-noses In Commercial Systemsmentioning

confidence: 99%

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

Sierra-Padilla

García-Guzmán

López-Iglesias

et al. 2021

Sensors

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Conducting polymers (CPs) are extensively studied due to their high versatility and electrical properties, as well as their high environmental stability. Based on the above, their applications as electronic devices are promoted and constitute an interesting matter of research. This review summarizes their application in common electronic devices and their implementation in electronic tongues and noses systems (E-tongues and E-noses, respectively). The monitoring of diverse factors with these devices by multivariate calibration methods for different applications is also included. Lastly, a critical discussion about the enclosed analytical potential of several conducting polymer-based devices in electronic systems reported in literature will be offered.

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An electronic nose may sniff out amyotrophic lateral sclerosis

Cited by 13 publications

References 15 publications

The electronic nose technology in clinical diagnosis: A systematic review

The electronic nose technology in clinical diagnosis: A systematic review

Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

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