An electronic memory aid to support prospective memory in patients in the early stages of Alzheimer's disease: A pilot study

Oriani, M.; Moniz-Cook, Esmé; Binetti, Giuliano; Zanieri, Gabriele; Frisoni, Giovanni B.; Geroldi, Cristina; Vreese, Luc P. De; Zanetti, Orazio

doi:10.1080/1360786021000045863

Cited by 76 publications

(40 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Future studies might also examine the association between qualitative aspects of ProM performance and neurovirologic (e.g., biomarkers of macrophage activation), neuroimaging, and neuropathologic variables in HIV-1 infection. Also, the present findings are not specific to HIV-infection, nor to conditions with fronto-striatal systems disruption, since ProM deficits are evident in numerous neurologic conditions (e.g., Alzheimer's disease; Oriani et al, 2003).…”

Section: Discussionmentioning

confidence: 93%

Prospective Memory in HIV-1 Infection

Carey

Woods

Rippeth

et al. 2006

Journal of Clinical and Experimental Neuropsychology

126

172

View full text Add to dashboard Cite

The cognitive deficits associated with HIV-1 infection are thought to primarily reflect neuropathophysiology within the fronto-striato-thalamo-cortical circuits. Prospective memory (ProM) is a cognitive function that is largely dependent on prefronto-striatal circuits, but has not previously been examined in an HIV-1 sample. A form of episodic memory, ProM involves the complex processes of forming, monitoring, and executing future intentions vis-à-vis ongoing distractions. The current study examined ProM in 42 participants with HIV-1 infection and 29 demographically similar seronegative healthy comparison (HC) subjects. The HIV-1 sample demonstrated deficits in time-and event-based ProM, as well as more frequent 24-hour delay ProM failures and task substitution errors relative to the HC group. In contrast, there were no significant differences in recognition performance, indicating that the HIV-1 group was able to accurately retain and recognize the ProM intention when retrieval demands were minimized. Secondary analyses revealed that ProM performance correlated with validated clinical measures of executive functions, episodic memory (free recall), and verbal working memory, but not with tests of semantic memory, retention, or recognition discrimination. Taken together, these findings indicate that HIV-1 infection is associated with ProM impairment that is primarily driven by a breakdown in the strategic (i.e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis.HIV-1 infiltrates the brain during the initial phases of systemic infection where it promotes neuronal and glial injury (e.g., dendritic simplification) (Petito, 2004). Prevalent throughout the neocortex and white matter tracts, HIV-1-associated neuropathology is perhaps most

show abstract

Section: Discussionmentioning

confidence: 93%

Prospective Memory in HIV-1 Infection

Carey

Woods

Rippeth

et al. 2006

Journal of Clinical and Experimental Neuropsychology

126

172

View full text Add to dashboard Cite

show abstract

“…Several case series and very small comparative studies with less than 20 participants have suggested that this approach may have some potential clinical utility, particularly for promoting improved functioning. [37][38][39] Although the evidence base is preliminary, this approach appears to be initially valid and is simple and practical to implement.…”

Section: Memory Aidsmentioning

confidence: 99%

Nonpharmacological Treatment of Alzheimer Disease

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Ob sich die Einsetzbarkeit der Geräte bessert, wenn in Zukunft eine Generation von Demenzpatienten heranwächst, die über langjäh-rige Erfahrung (d. h. prozedurales Wissen) bei der Bedienung von Handys und Palms verfügen werden, bleibt abzuwarten. Während zum Einsatz elektronischer Gedächtnishilfen bei nichtprogressiver Amnesie bereits replizierte Wirksamkeitsnachweise vorliegen, existiert für Alzheimer-Patienten bisher nur eine Einzelfallstudie [35], bei der 4 Patienten mit leichter Gedächtnisstörung bei der Bearbeitung prospektiver Gedächtnisaufgaben vom Gebrauch einer elektronischen Gedächt-nishilfe mehr profitierten konnten als von einer geschriebenen Liste. Da es sich bei den Tätigkeiten um artifizielle, vom Versuchsleiter vorgegebene Handlungen im klinischen Setting handelte (z.…”

Section: Externe Gedächtnishilfenunclassified

Kognitives Training bei Alzheimer-Demenz

Werheid

Thöne-Otto

2006

Nervenarzt

View full text Add to dashboard Cite

Memory rehabilitation in dementia patients is gaining importance. Among the increasing number of people affected by Alzheimer's dementia (AD), the number detected in early stages of the disease is growing disproportionately quickly. The reasons are obvious: improved clinical assessment in the initial disease stage, increased sensitization of the elderly towards cognitive deficits, and the prescription of drugs retarding cognitive decline. Given the limited success of early training programs in the 1980s, skepticism towards cognitive training in dementia is still common among clinicians. However, recent international studies in the field give reason for cautious optimism. Memory therapy in the early-to-moderate stages of AD can be successful, if it is tailored to patients' individual daily problems and based on their residual cognitive capacities. The present paper gives an overview of recent findings in clinical and cognitive neuroscience which have led to a conceptual change in the memory rehabilitation of patients with dementia. Based on a review of general principles and rehabilitation techniques proven successful in recent research, recommendations are formulated for future studies evaluating cognitive therapy in dementia.

show abstract

An electronic memory aid to support prospective memory in patients in the early stages of Alzheimer's disease: A pilot study

Cited by 76 publications

References 26 publications

Prospective Memory in HIV-1 Infection

Prospective Memory in HIV-1 Infection

Nonpharmacological Treatment of Alzheimer Disease

Kognitives Training bei Alzheimer-Demenz

Contact Info

Product

Resources

About