1969
DOI: 10.1679/aohc1950.30.467
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An Electron Microsopic Study of the Specific Granules in the Atrial Muscle Cell upon the Administration of Agents Affecting Autonomic Nerves

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Cited by 24 publications
(6 citation statements)
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References 8 publications
(7 reference statements)
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“…The present findings on the formation and release as well as the constant occurrence of the specific granules in various species seem to provide further support to our view (OTSUKA, OKAMOTO and TOMISAWA, 1969;OKAMOTO, 1969) that the granules contain substances which play an indispensable role in the function of atrial cells. The fact that the number of the specific granules varies sensitively with the effect of some autonomic drugs which interfere with the catecholamine metabolism (OTSUKA, OKAMOTO and TOMISAWA, 1969;OKAMOTO, 1969) suggests that they may be closely related to the function of the atrial autonomic nervous system of the heart. Also these granules might be correlated to the stimulus conduction in the atria, because they occur only in the atria which lack an obvious conduction system, whereas the ventricles with a well developed conduction systemm have few granules.…”
Section: Discussionsupporting
confidence: 89%
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“…The present findings on the formation and release as well as the constant occurrence of the specific granules in various species seem to provide further support to our view (OTSUKA, OKAMOTO and TOMISAWA, 1969;OKAMOTO, 1969) that the granules contain substances which play an indispensable role in the function of atrial cells. The fact that the number of the specific granules varies sensitively with the effect of some autonomic drugs which interfere with the catecholamine metabolism (OTSUKA, OKAMOTO and TOMISAWA, 1969;OKAMOTO, 1969) suggests that they may be closely related to the function of the atrial autonomic nervous system of the heart. Also these granules might be correlated to the stimulus conduction in the atria, because they occur only in the atria which lack an obvious conduction system, whereas the ventricles with a well developed conduction systemm have few granules.…”
Section: Discussionsupporting
confidence: 89%
“…The atria of rodents tend to contain a larger number of granules with a larger diameter, while the granules of the ungulata are conspicuously small in number and size. As suggested by our previous papers (OTSUKA, OKAMOTO and TOMISAWA, 1969;OKAMOTO, 1969), the atrial specific granules are presumed to contain substances which are important in the function of atrial muscle cells and their quantative differences among species revealed by the present study may imply the possible differences in the metabolic rates in the cells.…”
Section: Discussionsupporting
confidence: 64%
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“…Previous work supports the concept that autonomic neuronal dysfunction might result in altered ANH secretion. Reserpine reduces atrial granularity [15] and betablockers can increase atrial granularity [16]. Recent investigations have demonstrated increased secretion of ANH from isolated rat atria exposed to epinephrine and acetylcholine [17,18], although these results have been questioned due to the absence of appropriate controls [29].…”
Section: Discussionmentioning
confidence: 99%
“…Areas of the cardiac atria that are very sensitive to small changes in atrial stretch are richly supplied with nerve endings from the autonomic nervous system [14]. Changes in the number of atrial granules have been observed following manipulations of autonomic nervous system activity [15,16]. Recently, adrenergic and cholinergic agonists have been shown to stimulate ANH release in vitro [17,18] and in vivo [19].…”
Section: Introductionmentioning
confidence: 99%