1986
DOI: 10.1016/0167-0115(86)90162-x
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Plasma levels of immunoreactive atrial natriuretic hormone in patients with diabetes mellitus

Abstract: In order to determine whether atrial natriuretic hormone (ANH) secretion is altered in diabetic patients with autonomic neuropathy, plasma immunoreactive ANH (IR-ANH) levels were measured in 23 patients with insulin-dependent diabetes mellitus, 12 of whom had definite cardiac autonomic neuropathy determined by noninvasive maneuvers. Levels were also measured in 31 healthy control subjects. Whereas only one of the 11 diabetics without cardiac autonomic neuropathy had elevated IR-ANH levels, four of the 12 diabe… Show more

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Cited by 20 publications
(7 citation statements)
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“…However, in these studies we evaluated plasma ANF in type I and II diabetic patients with good metabolic control, suggesting the previous findings as the consequence of volume expansion associated with hyperglycemia (8,13). In fact, raised levels of plasma ANF have been described in these conditions (7,(14)(15)(16). On the other hand, the normality of ANF levels that we found in normotensive type I and type II diabetic patients could be related to the absence of diabetes-related autonomic neuropathy and/or nephropathy.…”
Section: Discussionmentioning
confidence: 73%
“…However, in these studies we evaluated plasma ANF in type I and II diabetic patients with good metabolic control, suggesting the previous findings as the consequence of volume expansion associated with hyperglycemia (8,13). In fact, raised levels of plasma ANF have been described in these conditions (7,(14)(15)(16). On the other hand, the normality of ANF levels that we found in normotensive type I and type II diabetic patients could be related to the absence of diabetes-related autonomic neuropathy and/or nephropathy.…”
Section: Discussionmentioning
confidence: 73%
“…It is also well-known that a dysautonomia involving essentially the vagal cardiac innervation develops in many patients with diabetes mellitus. Kann, Grekin and Vinik (1986) found recently that elevated plasma ANP concentrations occurred with greater frequency in diabetic patients with autonomic neuropathy since only one of the eleven intact diabetics included in their study had high ANP levels whereas the proportion was four out of twelve for the patients with cardiac dysautonomia. These results are in agreement with our previous findings in uremic patients on maintenance hemodialysis (Pruszczynski et al 1987).…”
Section: Discussionmentioning
confidence: 92%
“…Both groups, however, exhibited normal circa¬ dian PRA and plasma aldosterone rhythms with peak values in the early morning. A reciprocal change in the levels of plasma ANP and PRA or plasma aldosterone has been reported in diabetic subjects with poor glycémie control (10) and microvascular complications (11)(12)(13)(14), whereas normal circadian PRA and plasma aldosterone rhythms with peaks in the early morning occur irrespective of glycémie control and microvascular complications (26). Our two diabetic groups had similar glycémie control with high fasting plasma glucose and HbAlc.…”
Section: Discussionmentioning
confidence: 98%
“…Sodium retention and extracellular volume expansion are even more pronounced in diabetic patients with postural hypotension and/or nephropathy (5,29,31). Since cardiac autonomie dysfunction does not directly affect ANP release (13,(32)(33)(34), such water and sodium retention during daytime and its central shift with night recumbency in diabetic patients with autonomie dysfunction, especially those with postural hypotension, may contribute to elevations in BP (1) and plasma ANP (35), falls in PRA and plasma aldosterone (28,29), altered diurnal changes in BP and plasma ANP with their nocturnal rises, and nocturnal diuresis and natriuresis (6).…”
Section: Discussionmentioning
confidence: 98%
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