An electron‐microscopic study of the endo‐metrioid adenocarcinoma of the ovary and a comparison of its fine structure with that of normal endometrium and of adenocarcinoma of the endometrium

Cummins, Patricia A.; Fox, H.; Langley, F. A.

doi:10.1002/path.1711130306

Cited by 34 publications

(3 citation statements)

References 31 publications

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“…The single tumor classified as an anaplastic adenocarcinoma was histologically similar to those induced in rats by the clipping method with 7,12-dimethylbenz-(a)anthracene (18,19). The tumor strongly resembled neoplasms of the uterine endometrium occasionally encountered in our rats and may represent the equivalent of the endometrioid adenocarcinoma reported in women (7)(8)(9)20).…”

Section: Discussionsupporting

confidence: 72%

Ovarian neoplasia in the Sprague-Dawley rat.

Lewis

1987

Environ Health Perspect

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Macroscopic and microscopic characteristics of 210 spontaneous ovarian tumors from 7748 Sprague-Dawley rats are described. The tumors were classified as tubular adenoma, anaplastic adenocarcinoma, papillary cystadenoma, papillary cystadenocarcinoma, mesothelioma, sertoliform tubular adenoma, Sertoli's cell tumor, granulosa cell tumor, thecal cell tumor, polycystic sex cord/stromal tumor, and lipoid cell tumor. The histogenesis of the tumor types is discussed.ImagesPLATE 1.PLATE 2.PLATE 3.PLATE 4.PLATE 5.PLATE 6.PLATE 7.PLATE 8.PLATE 9.PLATE 10.PLATE 11.PLATE 12.PLATE 13.PLATE 14.PLATE 15.PLATE 16.PLATE 17.PLATE 18.PLATE 19.PLATE 20.PLATE 21.PLATE 22.PLATE 23.

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Section: Discussionsupporting

confidence: 72%

Ovarian neoplasia in the Sprague-Dawley rat.

Lewis

1987

Environ Health Perspect

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“…In the literature, figures as high as 88% endometrioid ovarian histology in simultaneously detected endometrial and ovarian carcinomas are reported. 32 No stimulating factor has yet been described to account for the effect, although estrogens, 34 androgens, 10 and endometriosis 35,36 have been hypothesized as contributing factors.…”

Section: Discussionmentioning

confidence: 95%

Coexisting Ovarian Malignancy in Young Women With Endometrial Cancer

Walsh

Holschneider

Hoang

et al. 2005

Obstetrics & Gynecology

212

118

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“…Whereas solid and cys tic ovarian carcinomas have been exten sively studied morphologically and ultra structurally [4][5][6][7][8][9][10][11][12][13][14], cells present in effusions have received much less attention. Desmo somes were noted in ovarian carcinoma cell clusters [15] as were irregular microvilli [16,17], The morphologic dedifferentiation of mésothélial cells in vitro was described by Monif and Daly [18].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Morphologic Characterization of Human Ovarian Carcinoma Cell Clusters Present in Effusions

Allen

Porter²,

Gamarra³

et al. 1987

Pathobiology

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Serous, mucinous, endometrioid and clear cell human ovarian carcinoma cells were isolated as multicellular aggregates from patient effusions by filtration on nylon mesh of defined porosity and examined by light microscopy. The cell clusters ranged from compact to loosely adherent groups of cells to spheroids with a central lumen surrounded by a cell monolayer. There was considerable variation in cluster morphology between effusions from different patients as well as within effusion from the same patient. Apparent budding of clusters was observed as well as different stages of cluster growth and development. This was observed for all histologic types studied. Electron microscopy of serous, mucinous and clear cell types showed that cells forming clusters were attached to each other by desmosomes, demonstrating that cluster formation did not result from a nonspecific stickiness of cells. Irregular micro villi were present on the external periphery of the various carcinoma cells and a prominent glycocalyx was present on the surface of mucinous carcinoma cells. Extensive interdigitation of cytoplasmic extensions and extended villi was present in mucinous and serous clusters which appeared to strengthen cluster cohesiveness. Nuclei were irregular with prominent nucleoli frequently present. The cell clusters usually remained intact and viable in culture but generally did not attach to glass or plastic substrata, whereas mesothelial cells and nonactivated histiocytes rapidly attached. When carcinoma cell clusters did attach, they were resistant to detachment by trypsin-EDTA treatment, in contrast to the nonmalignant cells.

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An electron‐microscopic study of the endo‐metrioid adenocarcinoma of the ovary and a comparison of its fine structure with that of normal endometrium and of adenocarcinoma of the endometrium

Cited by 34 publications

References 31 publications

Ovarian neoplasia in the Sprague-Dawley rat.

Ovarian neoplasia in the Sprague-Dawley rat.

Coexisting Ovarian Malignancy in Young Women With Endometrial Cancer

Isolation and Morphologic Characterization of Human Ovarian Carcinoma Cell Clusters Present in Effusions

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