Ovarian neoplasia in the Sprague-Dawley rat.

Lewis, David

doi:10.1289/ehp.877377

Cited by 22 publications

(22 citation statements)

References 25 publications

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“…The overall occurrence of mesothelioma was 0.4% (11 out of 2669), which is quite low as compared to 2.34% occurrence of this neoplasm in the tunica vaginalis propria and peritonium of Fischer rats reported by Gould (1977). In the present study, 0.68% occurrence of ovarian neoplasms (mainly granulosa cell tumor) is quite low as compared to 2.7% reported by Lewis (1987). In his study, the most common tumor was ovarian tubular adenoma followed by anaplastic adenocarcinoma, and papillary cystadenoma/cystadenocarcinoma.…”

Section: Discussioncontrasting

confidence: 64%

Spontaneous neoplasms in aged sprague-dawley rats

Chandra¹,

Riley²,

Johnson³

1992

Arch Toxicol

110

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Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid parafollicular cell adenomas (3.6%), fibromas and squamous cell papillomas of the skin and hepatocellular adenomas (2.0% in each), malignant lymphoma lymphocytic (1.9%), histiocytic sarcomas (1.4%), and adrenal cortical adenomas (1.2%). In female rats, the most common neoplasms were of mammary gland origin (31.3%: fibroadenoma 19.0%, adenocarcinomas 8.8%, and adenomas 3.5%) followed by thyroid parafollicular cell adenomas (2.9%), uterine endometrial stromal polyps (2.6%), adrenal cortical adenomas (1.9%), malignant lymphoma lymphocytic (1.6%), fibromas in the skin (1.3%), and pancreatic islet cell adenoma (1.1%). Metastases were observed from pheochromocytomas, hepatocellular carcinomas, nephroblastomas, renal pelvis transitional cell carcinoma, interstitial cell tumor and seminoma of the testes, Zymbal's gland adenocarcinomas, and mammary adenocarcinomas.

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Section: Discussioncontrasting

confidence: 64%

Spontaneous neoplasms in aged sprague-dawley rats

Chandra¹,

Riley²,

Johnson³

1992

Arch Toxicol

110

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“…To our knowledge, there have been a few reports concerning spontaneous mesotheliomas in Sprague-Dawley rats. Based on the descriptions, the primary sites were the atriocaval location and ovary 9 – 11 . The exact primary site in this case was unclear, but it was evident that the tumor originated in the mesothelium of the thoracic organs or tissues.…”

mentioning

confidence: 88%

“…The most common site is the genital serosa, but it also grows and spreads into the peritoneal cavity in some cases 6 – 8 . To our knowledge, spontaneous mesotheliomas do not commonly occur in Sprague-Dawley rats, and only a few cases have been reported 9 – 11 . Recently, we encountered a spontaneous mesothelioma in the thoracic cavity of a mature male Sprague-Dawley rat.…”

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confidence: 97%

Malignant Mesothelioma in the Thoracic Cavity of a Crj:CD(SD) Rat Characterized by Round Hyalinous Stroma

et al. 2010

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Spontaneous malignant mesothelioma was found in a 104-week-old male Crj:CD(SD) rat. The tumor was scattered on the surface of the lung, heart, mediastinal pleura and thoracic wall and metastasized to the alveolar septa. Histopathologically, small flattened or cuboidal tumor cells proliferated with stroma, formed almost normal papillary structures and reacted positively to colloidal iron stain and immunohistochemical staining for mesothelin. Round hyalinous stromata were pronounced, which is a characteristic feature, and the possible reason for this is as follows; at first, a small amount of collagen fibers was formed in the center of the clusters of several tumor cells, and then the cell clusters expanded like balloons with an increase in the collagen fibers.

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“…Rat ovarian tumors can be roughly divided into 3 main histological categories classified by their presumed histogenesis [4][5][6] . Sex cord-stromal tumors are the most common, both spontaneous and induced rat ovarian neoplasms [1][2][3][7][8][9][10][11] . Ovarian teratoma classified as germinal cell tumor is extremely rare in rats [1][2][3][4][5][6][7][8][9][10][11] .…”

mentioning

confidence: 99%

“…Sex cord-stromal tumors are the most common, both spontaneous and induced rat ovarian neoplasms [1][2][3][7][8][9][10][11] . Ovarian teratoma classified as germinal cell tumor is extremely rare in rats [1][2][3][4][5][6][7][8][9][10][11] . In this report, we describe the histopathological characteristics of the first case of an immature (malignant) ovarian teratoma in a juvenile Crj:CD(SD)IGS rat.…”

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confidence: 99%

A Spontaneous Ovarian Immature Teratoma in a Juvenile Rat

Tsubota¹,

Yoshizawa²,

Fujihira³

et al. 2004

J Toxicol Pathol

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A spontaneous ovarian immature teratoma characterized by the presence of tissue derivatives of endoderm, mesoderm and ectoderm was investigated histopathologically in a 6-week-old juvenile Crj:CD(SD)IGS rat. The various kinds of tissue components observed in this teratoma were mainly mature elements derived from three embryonic germ layers, such as nervous tissue, skin, pancreas, salivary gland, gastrointestinal tract, respiratory tracts, striated and smooth muscle, bone with bone marrow, cartilaginous tissue and adipose tissue. Remarkable features were that this teratoma contained immature tissues intermingled with mature tissues, which typically took the form of primitive neuroepithelial rosettes and tubules and islands of immature cartilage, showing evidence of malignancy. A small yolk sac carcinomalike focus was also observed. Neither invasion nor distant metastases were found in the other organs and tissues. This is the first report of an ovarian immature teratoma in a rat.

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Ovarian neoplasia in the Sprague-Dawley rat.

Cited by 22 publications

References 25 publications

Spontaneous neoplasms in aged sprague-dawley rats

Spontaneous neoplasms in aged sprague-dawley rats

Malignant Mesothelioma in the Thoracic Cavity of a Crj:CD(SD) Rat Characterized by Round Hyalinous Stroma

A Spontaneous Ovarian Immature Teratoma in a Juvenile Rat

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