An electron microscopic study of regeneration and satellite cells in human muscle

Shafiq, Saiyid A.; Gorycki, Michael A.; Milhorat, A. T.

doi:10.1212/wnl.17.6.567

Cited by 93 publications

(16 citation statements)

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“…Target fibres have been described ultrastructurally in limb muscle in motor neurone disease by Schotland (1969). Lipofuscin accumulations have been reported in limb muscle of patients with this disorder by Shafiq et al (1967) and Mumenthaler (1970) described grossly abnormal changes in limb muscle, similar to those observed here.…”

Section: Discussionsupporting

confidence: 83%

“…Each of the electron microscopic findings noted has also previously been reported in limb muscle biopsies from patients with the corresponding conditions. Thus, in Duchenne muscular dystrophy, numerous vesicles, swollen mitochondria, and focal contractions were described in peroneus brevis muscle by Santa (1969) while the occurrence of frequent satellite cells was reported in limb muscle by Shafiq et al (1967). Subsarcolemmal intramitochondrial crystalline inclusions have previously been reported in a patient with limb-girdle dystrophy by Fardeau (1970).…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Intercostal muscle biopsy in human neuromuscular disease. Histochemical and electron microscopic studies.

Stern¹,

Payne²,

Gruener³

et al. 1975

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 89%

Intercostal muscle biopsy in human neuromuscular disease. Histochemical and electron microscopic studies.

Stern¹,

Payne²,

Gruener³

et al. 1975

Journal of Neurology, Neurosurgery & Psychiatry

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“…Einerseits werden die Satellitenzellen als Regenerations zellen diskutiert, anderseits denkt man an eine Entdifferenzierung der Myonuklei zu Myo blasten, die dann wieder teilungsfähig werden und somit gewissermassen embryonalen Cha rakter annchmen [Carlson, 1973]. Diese Frage ist jedoch noch nicht eindeutig geklärt [All brook, 1962: Walker, 1963: Lee, 1965: Muh et al, 1965: Church, 1966: Shafiq et al, 1967Hess und Rosner, 1970;Terävainen, 1970;Allbrook et al, 1970] [ 1963,1964] und Thompson [ 1971 a,b], denen zufolge die vorausgehende Denervation das Angehen eines freien Muskeltransplan tates erheblich verbessert. Thompson [1971a, b] …”

Section: Materials Und Methodeunclassified

Lichtmikroskopische und elektronenoptische Untersuchungen morphologischer Veränderungen von Muskelfasern bei freier autologer Muskeltransplantation

Lischka¹,

Holle²,

Freilinger³

1977

Cells Tissues Organs

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The extensor digitorum longus muscle of the rat was denervated and transplanted onto the vastus lateralis muscle of the same limb 1 or 2 weeks after denervation. The morphological changes appearing after transplantation were examined by light and electron microscopy. Only three to four superficial layers of muscle fibres remained unchanged after transplantation. The other parts of the transplanted muscle degenerated nearly entirely during the first 10 days. The myofibrils were removed by macrophages, thus within the tubes of basal lamina no contractile material could be observed. In a second period, regeneration of myofilaments took place. 6 weeks after transplantation, newly formed muscle could be observed, capable of normal function. The diameter of the fibres, however, was smaller and the connective tissue between the fibres markedly increased as compared to the normal muscle of the other side. The importance of the findings for muscle transplantation, especially the relationship between satellite cells and myoblasts, is discussed.

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“…Muscle biopsies from patients with progressive muscular dystrophy, Duchenne muscular dystrophy or polymyositis contained more satellite cells associated with damaged and regenerating myofibres. These satellite cells had a morphology that indicated that they were not quiescent, since they contained comparatively large amounts of cytoplasm with numerous ribosomes attached to rough endoplasmic reticulum [69,70]. Therefore, after both physical and pathological injury, cells in the satellite cell location exhibited a morphology similar to that of myoblasts, and so appeared to be their precursors.…”

Section: Introductionmentioning

confidence: 99%

The muscle satellite cell at 50: the formative years

2011

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In February 1961, Alexander Mauro described a cell 'wedged' between the plasma membrane of the muscle fibre and the surrounding basement membrane. He postulated that it could be a dormant myoblast, poised to repair muscle when needed. In the same month, Bernard Katz also reported a cell in a similar location on muscle spindles, suggesting that it was associated with development and growth of intrafusal muscle fibres. Both Mauro and Katz used the term 'satellite cell' in relation to their discoveries. Today, the muscle satellite cell is widely accepted as the resident stem cell of skeletal muscle, supplying myoblasts for growth, homeostasis and repair.Since 2011 marks both the 50th anniversary of the discovery of the satellite cell, and the launch of Skeletal Muscle, it seems an opportune moment to summarise the seminal events in the history of research into muscle regeneration. We start with the 19th-century pioneers who showed that muscle had a regenerative capacity, through to the descriptions from the mid-20th century of the underlying cellular mechanisms. The journey of the satellite cell from electron microscope curio, to its gradual acceptance as a bona fide myoblast precursor, is then charted: work that provided the foundations for our understanding of the role of the satellite cell. Finally, the rapid progress in the age of molecular biology is briefly discussed, and some ongoing debates on satellite cell function highlighted.

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An electron microscopic study of regeneration and satellite cells in human muscle

Cited by 93 publications

References 0 publications

Intercostal muscle biopsy in human neuromuscular disease. Histochemical and electron microscopic studies.

Intercostal muscle biopsy in human neuromuscular disease. Histochemical and electron microscopic studies.

Lichtmikroskopische und elektronenoptische Untersuchungen morphologischer Veränderungen von Muskelfasern bei freier autologer Muskeltransplantation

The muscle satellite cell at 50: the formative years

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