An electron-accepting half-sandwich iridium(iii) complex for the treatment of hypoxic tumors via synergetic chemo- and phototherapy

Abstract

Here is a red light-responsive half-sandwich iridium(iii) complex designed for treating hypoxic tumors through a synergistic effect involving apoptosis and ferroptosis.

Synthesis, characterization, and anticancer activity of Ru(p-cymene) complexes bearing pyrazolyl–pyridine type ligands

“…5 It has been widely used in clinics to treat various types of cancer worldwide. 5–7 It is important to note that although cis -platin has been recognized as a successful chemotherapeutic drug, the impediments and side effects of cis -platin have steered the scientific community to focus its attention on alternative metallodrugs that have minimal side effects and enhanced efficacy against cancer. 3,8 Among the several metal complexes under investigation with the hope of potential anticancer drug candidates, ruthenium-based compounds have emerged for a broad spectrum of activity.…”