clinical Question: In a healthy adult population, which push-up position produces the greatest mean serratus anterior (SA) activation, expressed as a percentage of maximum voluntary isometric contraction (MVIC)? clinical Bottom line: In a healthy population, there is moderate evidence to support the use of the standard push-up on an unstable surface, elbow push-ups on stable and unstable surfaces, wall push-ups on an unstable surface, the full weight-bearing position using the Cuff Link system, and all three hand positions (shoulder width, wide base, and narrow base) with and without the use of the Perfect Pushup TM handgrips for the purpose of SA strengthening. These exercises produced a mean SA activation of at least 50% of the MVIC in the four cross-sectional studies that were reviewed for this critically appraised topic.