An Electrochemical Sensor Based on Reduced Graphene Oxide Modified Carbon Paste Electrode for Curcumin Determination in Human Blood Serum

Abstract

A sensitive, accurate electrochemical sensor based on reduced graphene oxide modified carbon paste electrode (RGO/CPE) was developed to measure curcumin levels in human blood serum. The as-prepared electrode (RGO/CPE) was verified to outperform bare carbon paste electrode (CPE), with increased oxidation and reduction peaks at +0.505 V and +0.408 V, respectively. Curcumin measurement was performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. RGO/CPE showed a desirable linear response towards curcumin, within the concentration range of 10-6000 µM; the detection limit (S/N = 3) was 3.183 µM. Moreover, electrochemical impedance spectroscopy (EIS) and field emission scanning electron microscope (FESEM) were applied to gain further insight into the electrochemical behavior of the proposed electrode. The results revealed that the usage of RGO caused increased sensitivity of the sensor response to curcumin; therefore, RGO/CPE can be considered a promising electrochemical sensor for curcumin determination in human blood serum.

Nitrogen-doped fluorescence carbon dots as multi-mechanism detection for iodide and curcumin in biological and food samples

“…At present, various detection techniques have been successfully developed to determinate iodide ions and curcumin, such as chromatography [ 13 , 14 ], capillary electrophoresis [ 15 , 16 ], electrochemistry [ 17 , 18 ], and so on. Although these methods possess high accuracy and satisfactory sensitivity, they still display some disadvantages, such as sophisticated instrumentation, complicated sample pretreatment, tedious operation procedures, and unstable electrodes, which are limited to some extent to apply extensively.…”

A reduced graphene oxide-β-cyclodextrin nanocomposite-based electrode for electrochemical detection of curcumin

“…This was an irreversible oxidation process, in good accordance with previous reports. 53,54 A very small oxidation peak at the surface of GC/GO and GC/β-CD was also observed. These results demonstrated that CM intensely accumulated at the surface of GC/β-CD–rGO during the incubation, and, β-CD–rGO modified electrode significantly increased the sensitivity of electrode for CM sensing/measuring.…”

Degradation‐triggered release from biodegradable metallic surfaces

“…Nevertheless, there was a significant difference in curcumin oxidation peak current intensity between the c‐Zn and c‐Fe samples as higher and more intense peaks were observed for the former. The enhancement of curcumin oxidation peak current signified the higher concentration of curcumin in the media 54‐57 . Since a higher curcumin release has been observed for the c‐Zn, more oxidation of curcumin was expected to take place in the media compared to that of c‐Fe.…”