An efficient synthesis of novel spiro[indole-3,8′-pyrano[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidine derivatives via organobase-catalyzed three-component reaction of malononitrile, isatin and heterocyclic-1,3-diones

Abstract

Contents PageX-ray crystallographic data of compound 6c S2Copies of 1 H NMR, 13 C NMR, IR and Mass spectra of 6a-6q S3-S36

Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-d]pyrimidine core

“…The procedure reported by Hosseini et al 131 delivered reduced the reaction time (10–60 min), green technique, and exceptional yields (80–96%). Thus, solvent-free one-pot multicomponent reactions of [1,3,4]thiadiazolo-pyrimidinones 62 with malononitrile, and isatin derivatives by heating under catalytic conditions of DABCO gave the anticipated 9′ H -spiro[indoline-3,8′-pyrano[1,3,4]-thiadiazolopyrimidine] derivatives 63.…”

Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs

“…22 Spirocyclic systems were also synthesized at a large scale by multicomponent reactions that involved the use of isatins as reactants. 23,24 The pyranodipyrimidines tended to form metal complexes with improved biological characteristics. 25 Amirnejat et al 26 evaluated the antibacterial potency of a series of synthesized 6-cyano-7-amino-2,4-dioxo-5-aryl-1,3,4,5-tetrahydro-2H-pyranoij2, 3-d]pyrimidines "prepared by multicomponent reactions using catalytic BaFe 12 O 19 nanoparticles".…”