An efficient synthesis of an optically active (-)-(3R, 4R, 5R)-4-(1-hydroxyl-isopropyl)-3-acetyloxyl-butyrolactone

Abstract

An optically active β-hydroxyl–γ-butyrolactone was synthesised from nonchiral starting material by employing reductive cleavage reaction, Sharpless asymmetric epoxidation and dihydroxylation as key steps. This strategy can be used to prepare many chiral β-hydroxyl–γ-butyrolactone analogues. The crystal structure of 10 was determined by X-ray crystallographs.