In this study, we prepared a series of 5-alkyl-2,6-dimethyl-3-arylfuro[3,2-c] pyridin-4(5H)-one derivatives via the reaction of 1-substitued 4-hydroxy-6-methylpyridin-2(1H)-ones with various nitrostyrenes using triethylamine as catalyst. This strategy not only provided various new 5-alkyl-2,6-dimethyl-3-arylfuro[3,2-c]pyridin-4(5H)-ones, but also expanded the scope of application of active intermediate nitrostyrenes. Meanwhile, this method has the advantages of inexpensive and easily available starting materials, step economy, metal-free catalytic system, good to excellent yields and operational simplicity.A total of 22 heterocyclic compounds were obtained to exhibit a broad substrate scope of the strategy.