An efficient, solvent-free microwave-assisted synthesis and antimicrobial screening of 1,6-dihydropyrimidine analogues

Novel Potent and Selective DPP-4 Inhibitors: Design, Synthesis and Molecular Docking Study of Dihydropyrimidine Phthalimide Hybrids

“…α-Phthalimido- o -toluic acid ( 8 ) and α-phthalimido- o -toluyl chloride ( 9 ) were prepared according to the literature [ 36 ]. 4,6-Diaryl-3,4-dihydropyrimidine-2( 1H )-thiones: 5a , 5b , 5c , 5f and 5h were synthesized following the reported procedure in the literatures [ 52 , 53 , 54 , 55 ].…”

Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation

“…The produced precipitate was filtered off, washed with water, and dried. Crystallization from ethanol afforded the pure products (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Yields: (78-95%).…”

“…Traditionally, these 4,6-disubstituted-pyrimidines have been prepared by cyclocondensation of chalcones with thiourea under the ultrasound, [7] microwave, [8] or refluxing conditions in basic media. [9][10][11][12] Notably, these syntheses require the formation and isolation of chalcones before conducting the cyclization step.…”

Facile synthesis of novel fluorine containing pyrazole based thiazole derivatives and evaluation of antimicrobial activity

“…Earlier our research group has synthesized different heterocyclic derivatives as potential antimicrobial agents [29][30][31][32][33]. In continuation to this, we synthesized 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(aryl)-4-5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-ones A series of compounds 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-ones (4a-q) were synthesized and structures of these compounds were elucidated by spectral (IR, 1 H NMR, 13 C NMR, mass spectra) analysis.…”