An efficient, one-pot synthesis of N-isatinylmethylthioacetic acid and its derivatives as potential anticancer agents

Features of interaction of 1-hydroxymethylisatin with certain P-, S-, and C-electrophiles

“…Thus, development of new approaches towards isatin functionalization is a promising research field. 1-Hydroxymethylisatin containing highly reactive hydroxyl group is among the promising substrates to do so [11].This work demonstrated the dual reactivity of 1hydroxymethylisatin I with respect to some C-, S-, and P-electrophiles. The reactions were carried out under the same conditions (benzene, 25°C) in the presence of equimolar amount of triethylamine.…”

“…Thus, development of new approaches towards isatin functionalization is a promising research field. 1-Hydroxymethylisatin containing highly reactive hydroxyl group is among the promising substrates to do so [11].…”