An efficient colorimetric biosensor for glucose based on peroxidase-like protein-Fe3O4 and glucose oxidase nanocomposites

Liu, Yan; Yuan, Min; Qiao, Longjiao

doi:10.1016/j.bios.2013.09.020

Cited by 116 publications

(40 citation statements)

References 27 publications

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“…Superparamagnetic iron oxide nanoparticles (SPIONs), including magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ), have been extensively utilized in biomedical applications, including as magnetic resonance imaging contrast agents, 1 for biocatalysis, 2 for biological separation, 3 for biosensing, 4 diagnostic medical devices, 5 and hyperthermia. Among these applications, hyperthermia 6 is a physical therapy in which SPIONs generate heat and thus kill cancer cells when they are exposed to an external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Liao¹,

Liu²,

Bastakoti³

et al. 2015

IJN

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Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe 3 O 4 ) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe 3 O 4 @Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe 3 O 4 @Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Liao¹,

Liu²,

Bastakoti³

et al. 2015

IJN

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“…Unique properties of Fe 3 O 4 nanoparticles, e.g. superparamagnetism, a large surface-tovolume ratio, high surface area, low toxicity, easiness of modification, offer enormous potential in the fields of immobilization of biomaterials [24][25][26][27], bioseparation [26][27][28][29][30][31] and bioengineering usage [32][33][34][35][36]. Moreover, the most important fact is the natural occurrence of iron oxides in human heart, spleen and liver [37], what implies their biocompatibility and non-toxicity at a physiological concentration.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new functionalized polymer-Fe3O4 nanocomposite particles

Bukowska¹,

Bukowski²,

Hus³

et al. 2017

Express Polym. Lett.

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Abstract. In this study, Fe 3 O 4 nanoparticles (NPs) were functionalized with copolymer or terpolymer bearing glycidyl methacrylate (GMA) moieties making them suitable for potential applications as drug delivery systems (DDS). For this purpose, the surface of magnetic nanoparticles was first coated with 3-(trimethoxysilyl) propyl methacrylate (MPS) by a silanization reaction to introduce reactive methacrylate groups onto the surface. Subsequently, monomers were grafted onto the surface of modified-MPS particles via two polymerization methods: seed emulsion (GMA, divinylbenzene, DVB, and styrene, S) and distillation -precipitation (GMA and DVB). The obtained nanocomposite particles were characterized by FTIR (Fourier transform infrared spectroscopy), DR UV-Vis (diffuse reflectance ultraviolet -visible spectroscopy), TEM (transmission electron microscopy) combined with EDS (energy dispersive X-ray spectroscopy) analysis and DLS (dynamic light scattering). FTIR spectroscopy showed that indeed a polymer -Fe 3 O 4 @MPS composite was obtained. TEM and EDS analysis showed that the seed emulsion method resulted in nanosized, 100 nm Fe 3 O 4 @MPS core/polymer shell NPs, forming long chains. On the contrary, the distillation -precipitation method caused the formation of an inverted structure, i.e. polymer core coated by a Fe 3 O 4 @MPS shell, which exhibited a very coarse size distribution varying from several hundreds to over 2 µm.

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“…Here, the PBMNPs served as an inexpensive horseradish peroxidase, HRP. 8 A recent study by Liu et al 9 reported that the incorporation of casein on magnetic nanoparticles helped to improve the affinity towards both H 2 O 2 and 3,3´,5,5´-tetramethylbenzidine (TMB) thus resulting in a simple, inexpensive, highly sensitive and selective method for glucose detection.…”

Section: Introductionmentioning

confidence: 99%

Manipulation of Fe/Au Peroxidase-Like Activity for Development of a Nanocatalytic-Based Assay

Bustami¹,

Moo‐Young²,

Anderson³

2017

JES

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An efficient colorimetric biosensor for glucose based on peroxidase-like protein-Fe3O4 and glucose oxidase nanocomposites

Cited by 116 publications

References 27 publications

Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Synthesis and characterization of new functionalized polymer-Fe3O4 nanocomposite particles

Manipulation of Fe/Au Peroxidase-Like Activity for Development of a Nanocatalytic-Based Assay

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