An efficient and inexpensive method for functionalizing metallic biomaterials used in orthopedic applications

Abstract

Implantations of metallic biomaterials are being carried out more and more frequently due to accident and population aging. Therefore, there is a need for new metallic implants which can combine properties such as durability, biocompatibility and affordability. In this study, multilayer functionalized 316 L stainless steel (SS) supports resistant to steam sterilization were presented. An electropolymerization of pyrrole was performed on SS supports to obtain a protective layer. This polypyrrole coating rendered SS surface resistant to corrosion. Then an electrodeposition of Calcium Phosphate (CaP) doped with increasing concentrations of silicon (Si) ranging from 0 to 2 mM was tested to improve support bone integration. The impacts of silicon addition in the CaP coating without or after steam sterilization were analyzed by profilometry, Scanning Electron Microscopy and Fourier Transform Infrared Spectroscopy. These latter revealed that CaP doped with 0.5 mM of Si constituted the optimal support formulation, presenting sterilization resistance and good biocompatibility.

Fibronectin Conformations after Electrodeposition onto 316L Stainless Steel Substrates Enhanced Early-Stage Osteoblasts’ Adhesion but Affected Their Behavior

“…PPy films had a thickness of 4.98 µm ± 0.15 µm and a low roughness of 0.27 µm ± 0.05 µm. In this study, the films obtained were thicker (4.9 µm vs. 2.2 µm) than those obtained by Hamdaoui S et al [37]. These results are consistent because the Py solution used was twice as concentrated as the one previously used in the lab.…”

Corrosion Protection of 316L SS by Cerium-Based Coatings: Effect of the Incorporation of Additives

“…It was reported that the NaSa is predominantly an anodic inhibitor [29]. In the case of molybdate was also used extensively as a corrosion inhibitor of iron and stainless steels over a wide-ranging temperature and pH range [11,13]. The anion positively affects the passivity breakdown and pitting initiation of 316L SS.…”

“…They are one of the oldest and most widely used anti-inflammatory drugs and also exhibit various recognized pharmacological roles such as anticancer, neuroprotective, antipyretic, skin antiaging, and antidiabetic effects [10]. It was reported that the presence of sodium salicylate in a polypyrrole coating improves the corrosion protection of 316L SS, promoting the formation of the passive layer on the surface of substrate [11,12]. Moreover, it has been informed a favorable in vivo vascular compatibility of a salicylate-based polymer coating employed as a drug-eluting for metallic stents [13].…”

Surface modification during hydroxyapatite powder mixed electric discharge machining of metallic biomaterials: a review

“…There is no need for surface preparation prior to EDM, and the process also converts the surface into a biocompatible oxide layer of significant thickness, increasing the biocompatibility of the substrate and creating a convenient environment for cell attachment and growth [93][94][95]. When compared to other surface modification procedures, the EDM process increases the micro-hardness, biocompatibility, wear, and corrosion resistance of implant surfaces by forming different carbides and intermetallic compounds on the coasted surface [96][97][98][99].…”